Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure
Autore:
Middlekauff, HR; Nitzsche, EU; Hoh, CK; Hamilton, MA; Fonarow, GC; Hage, A; Moriguchi, JD;
Indirizzi:
Univ Calif Los Angeles, Dept Med, Div Cardiol, Los Angeles, CA 90095 USA Univ Calif Los Angeles Los Angeles CA USA 90095 Los Angeles, CA 90095 USA Univ Basel, Sch Med, Dept Radiol, Div Nucl Med, CH-4031 Basel, SwitzerlandUniv Basel Basel Switzerland CH-4031 ucl Med, CH-4031 Basel, Switzerland Univ Basel, Med Ctr, CH-4031 Basel, Switzerland Univ Basel Basel Switzerland CH-4031 Med Ctr, CH-4031 Basel, Switzerland
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1714 - 1719
SICI:
8750-7587(200105)90:5<1714:EMMCOR>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RHYTHMIC FOREARM EXERCISE; CORTICAL BLOOD-FLOW; GROUP-III; AFFERENTS; CONTRACTION; RESPONSES; DISCHARGE; HUMANS; ACID;
Keywords:
exercise; sympathetic nervous system; renal circulation; congestive heart failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Middlekauff, HR Univ Calif Los Angeles, Dept Med, Div Cardiol, 47-123 CHS,10833 Le Conte Ave, Los Angeles, CA 90095 USA Univ Calif Los Angeles 47-123CHS,10833 Le Conte Ave Los Angeles CA USA 90095
Citazione:
H.R. Middlekauff et al., "Exaggerated muscle mechanoreflex control of reflex renal vasoconstriction in heart failure", J APP PHYSL, 90(5), 2001, pp. 1714-1719

Abstract

In heart failure (HF) patients, reflex renal vasoconstriction during exercise is exaggerated. We hypothesized that muscle mechanoreceptor control of renal vasoconstriction is exaggerated in HF. Nineteen HF patients and nineteen controls were enrolled in two exercise protocols: 1) low-level rhythmichandgrip (mechanoreceptors and central command) and 2) involuntary biceps contractions (mechanoreceptors). Renal cortical blood flow was measured by positron emission tomography, and renal cortical vascular resistance (RCVR)was calculated. During rhythmic handgrip, peak RCVR was greater in HF patients compared with controls (37 +/- 1 vs. 27 +/- 1 units; P < 0.01). Changein (<Delta>) RCVR tended to be greater as well but did not reach statistical significance (10 +/- 1 vs. 7 +/- 0.9 units; P = 0.13). RCVR was returnedto baseline at 2-3 min postexercise in controls but remained significantlyelevated in HF patients. During involuntary muscle contractions, peak RCVRwas greater in HF patients compared with controls (36 +/- 0.7 vs. 24 +/- 0.5 units; P < 0.0001). The <Delta> RCVR was also significantly greater in HF patients compared with controls (6 +/- 1 vs. 4 +/- 0.6 units; P = 0.05). The data suggest that reflex renal vasoconstriction is exaggerated in both magnitude and duration during dynamic exercise in HF patients. Given that the exaggerated response was elicited in both the presence and absence of central command, it is clear that intact muscle mechanoreceptor sensitivity contributes to this augmented reflex renal vasoconstriction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:50:14