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Titolo:
GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats
Autore:
Lee, SD; Nakano, H; Farkas, GA;
Indirizzi:
SUNY Buffalo, Dept Phys Therapy Exercise & Nutr Sci, Buffalo, NY 14214 USASUNY Buffalo Buffalo NY USA 14214 rcise & Nutr Sci, Buffalo, NY 14214 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1707 - 1713
SICI:
8750-7587(200105)90:5<1707:GMOVAP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; HYPOVENTILATION-SYNDROME; RESPIRATORY RESPONSE; GABA RECEPTORS; MECHANISM; NEUROTRANSMITTERS; HYPERCAPNIA; BICUCULLINE; METABOLISM; DEPRESSION;
Keywords:
respiration; exercise; gamma-aminobutyric acid; bicuculline; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Farkas, GA SUNY Buffalo, Dept Phys Therapy Exercise & Nutr Sci, 405 Kimball Tower,3435 Main St, Buffalo, NY 14214 USA SUNY Buffalo 405 Kimball Tower,3435 Main St Buffalo NY USA 14214
Citazione:
S.D. Lee et al., "GABAergic modulation of ventilation and peak oxygen consumption in obese Zucker rats", J APP PHYSL, 90(5), 2001, pp. 1707-1713

Abstract

Obesity is often associated with a reduced ventilatory response and a decreased maximal exercise capacity. GABA is a major inhibitory neurotransmitter in the mammalian central nervous system. Altered GABAergic mechanisms have been detected in obese Zucker rats and implicated in their hyperphagic response. Whether altered GABAergic mechanisms also contribute to regulate ventilation and influence exercise capacity in obese Zucker rats is unknown and formed the basis of the present study. Eight lean [317 +/- 18 (SD) g] and eight obese (450 +/- 27 g) Zucker rats were studied at 12 wk of age. Ventilation at rest and ventilation during hypoxic (10% O-2) and hypercapnic (4% CO2) challenges were measured by the barometric method. Peak O-2 consumption (VO2 (peak)) in response to a progressive treadmill test to exhaustion was measured in a metabolic treadmill. Ventilation and VO2 peak were assessed after administration of equal volumes of DMSO (vehicle) and the GABA(A) receptor antagonist bicuculline (1 mg/kg). In lean animals, bicuculline administration had no effect on ventilation and VO2 (peak). In obese rats, bicuculline administration significantly (P < 0.05) increased resting ventilation (465 +/- 53 and 542 +/- 72 ml<bullet>kg(-1). min(-1) for control and bicuculline, respectively), ventilation during exposure to hypoxia (899 +/- 148 and 1,038 +/- 83 ml . kg(-1). min(-1) for control and bicuculline, respectively), and O-V(2) (peak) (62 +/- 3.7 and 67 +/- 3.5 ml . kg(-0.75). min(-1) for control and bicuculline, respectively). However, in obese Zucker rats, ventilation in response to hypercapnia did not change after bicucullineadministration (608 +/- 96 vs. 580 +/- 69 ml . kg(-1). min(-1)). Our findings indicate that endogenous GABA depresses ventilation and limits exerciseperformance in obese Zucker rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 10:29:51