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Titolo:
Biventricular cardiac dysfunction after acute massive pulmonary embolism in the rat
Autore:
Sullivan, DM; Watts, JA; Kline, JA;
Indirizzi:
Carolinas Med Ctr, Dept Emergency Med, Div Res, Charlotte, NC 28232 USA Carolinas Med Ctr Charlotte NC USA 28232 Div Res, Charlotte, NC 28232 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 90, anno: 2001,
pagine: 1648 - 1656
SICI:
8750-7587(200105)90:5<1648:BCDAAM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGHT-VENTRICULAR-FUNCTION; ECHOCARDIOGRAPHY DOPPLER; MYOCARDIAL-FUNCTION; HEMORRHAGIC-SHOCK; BLOOD-FLOW; TNF-ALPHA; FOLLOW-UP; HYPERTENSION; HEART; HEMODYNAMICS;
Keywords:
pulmonary heart disease; tumor necrosis factor-alpha; myocardial contraction; shock; animal model; fibrinolysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Kline, JA Carolinas Med Ctr, Dept Emergency Med, Div Res, POB 32861, Charlotte, NC 28232 USA Carolinas Med Ctr POB 32861 Charlotte NC USA 28232 NC 28232 USA
Citazione:
D.M. Sullivan et al., "Biventricular cardiac dysfunction after acute massive pulmonary embolism in the rat", J APP PHYSL, 90(5), 2001, pp. 1648-1656

Abstract

Cardiac dysfunction has been documented in vivo after acute massive pulmonary embolism (AMPE). The present study tests whether intrinsic ventricular dysfunction occurs in rat hearts isolated after AMPE. AMPE was induced in spontaneously breathing ketamine-xylazine-anesthetized rats by thrombus infusion until mean arterial blood pressure (MAP) was similar to 40% of basal measurement. A hypotensive control group underwent controlled blood withdrawal to produce MAP similar to 40% of basal levels. Shams underwent identicalsurgical and anesthesia preparation but without pulmonary embolization. Hearts were perfused in isovolumetric mode, and simultaneous right ventricular (RV) and left ventricular (LV) pressures were measured. AMPE caused arterial hypotension with hypoxemia (PO2 = 50 +/- 14 Torr), acidemia (pH = 7.26 /- 0.11), and high lactate concentration (6.9 +/- 1.7 mM). Starling curvesfrom both ventricles demonstrated that AMPE significantly reduced ex vivo systolic contractile function in the RV (P = 0.031) and LV (P = 0.008) compared with both the hypotensive control and sham hearts. AMPE did not alter coronary flow or compliance in either ventricle. Soluble tumor necrosis factor-alpha decreased in the RV (P = 0.043) and LV (P = 0.005) tissue. These data support the hypothesis that AMPE produces intrinsic biventricular dysfunction and suggest that arterial hypotension is not the principal mechanism of this dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 09:25:23