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Titolo:
Does pretreatment anxiety predict response to either bupropion SR or sertraline?
Autore:
Rush, AJ; Batey, SR; Donahue, RMJ; Ascher, JA; Carmody, TJ; Metz, A;
Indirizzi:
Univ Texas, SW Med Ctr, Dept Psychiat, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 d Ctr, Dept Psychiat, Dallas, TX 75390 USA Glaxo Wellcome Inc, Div US Med Affairs, Res Triangle Pk, NC 27709 USA Glaxo Wellcome Inc Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA Glaxo Wellcome Inc, Clin Dev, Res Triangle Pk, NC 27709 USA Glaxo WellcomeInc Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA Univ Texas, SW Med Ctr, Acad Comp Serv, Dallas, TX 75390 USA Univ Texas Dallas TX USA 75390 Ctr, Acad Comp Serv, Dallas, TX 75390 USA
Titolo Testata:
JOURNAL OF AFFECTIVE DISORDERS
fascicolo: 1, volume: 64, anno: 2001,
pagine: 81 - 87
SICI:
0165-0327(200104)64:1<81:DPAPRT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUSTAINED-RELEASE BUPROPION; DOUBLE-BLIND; DEPRESSED OUTPATIENTS; MAJOR DEPRESSION; ANTIDEPRESSANT EFFICACY; PLACEBO; FLUOXETINE; DISORDER; AMITRIPTYLINE; IMIPRAMINE;
Keywords:
pretreatment anxiety; response prediction; bupropion SR; sertraline; retrospective data analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Rush, AJ Univ Texas, SW Med Ctr, Dept Psychiat, 5323 Harry Hines Blvd, Dallas, TX 75390 USA Univ Texas 5323 Harry Hines Blvd Dallas TX USA 75390 TX 75390 USA
Citazione:
A.J. Rush et al., "Does pretreatment anxiety predict response to either bupropion SR or sertraline?", J AFFECT D, 64(1), 2001, pp. 81-87

Abstract

Background: A common clinical belief is that mol-e sedating and/or serotonin-selective antidepressants are preferred for depressed patients with symptoms of anxiety compared with more activating and/or catecholamine-selective antidepressants. The purpose of this study was to determine whether higher baseline anxiety is associated with different antidepressant responses tobupropion sustained release (SR) or sertraline. Methods: A retrospective data analysis was conducted using pooled data from two identical 8-week, randomized, double-blind, placebo-controlled multicenter studies of bupropion SR (n = 234), sertraline (n = 225), and placebo (n = 233) in adult outpatients with recurrent, major depressive disorder. Anxiety symptoms were measured using the 14-item Hamilton Anxiety Rating Scale scores. Results: Baseline anxiety levels were not related to antidepressant response to treatment with either bupropion SR or sertraline, nor did they differentiate between responders to bupropion SR and responders to sertraline. Conclusions: Baseline anxiety levels do not appear to be a basis for selecting between bupropion SR and sertraline in the treatment of outpatients with major depressive disorder. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 20:33:27