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Titolo:
Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation
Autore:
Ma, QF; Anderson, DJ; Fritzsch, B;
Indirizzi:
Creighton Univ, Dept Biomed Sci, Omaha, NE 68178 USA Creighton Univ OmahaNE USA 68178 v, Dept Biomed Sci, Omaha, NE 68178 USA Dana Farber Canc Inst, Boston, MA 02115 USA Dana Farber Canc Inst Boston MA USA 02115 Canc Inst, Boston, MA 02115 USA CALTECH, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125CALTECH, Pasadena, CA 91125 USA
Titolo Testata:
JARO
fascicolo: 2, volume: 1, anno: 2000,
pagine: 129 - 143
SICI:
1525-3961(200009)1:2<129:N1NMED>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER-EAR; NERVOUS-SYSTEM; CHICK-EMBRYOS; MICE; GANGLIA; NEURONS; EXPRESSION; EFFERENTS; FIBERS; TRKB;
Keywords:
proneuronal genes; ear development; ganglion cell development; inner ear efferents; bHLH genes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Fritzsch, B Creighton Univ, Dept Biomed Sci, 2500 Calif Plaza, Omaha, NE 68178 USA Creighton Univ 2500 Calif Plaza Omaha NE USA 68178 E 68178 USA
Citazione:
Q.F. Ma et al., "Neurogenin 1 null mutant ears develop fewer, morphologically normal hair cells in smaller sensory epithelia devoid of innervation", JARO, 1(2), 2000, pp. 129-143

Abstract

The proneuronal gene neurogenin 1 (ngn1) is essential for development of the inner-ear sensory neurons that are completely absent in ngn1 null mutants. Neither afferent, efferent, nor autonomic nerve fibers were detected in the ears of ngn1 null mutants. We suggest that efferent and autonomic fibers are lost secondarily to the absence of afferents. In this article we showthat ngn1 null mutants develop smaller sensory epithelia with morphologically normal hair cells. In particular, the saccule is reduced dramatically and forms only a small recess with few hair cells along a duct connecting the utricle with the cochlea. Hair cells of newborn ngn1 null mutants show nostructural abnormalities, suggesting that embryonic development of hair cells is independent of innervation. However, the less regular pattern of dispersal within sensory epithelia may be caused by some effects of afferents or to the stunted growth of the sensory epithelia. Tracing of facial and state-acoustic nerves in control and ngn1 null mutants showed that only the distal, epibranchial, placode-derived sensory neurons of the geniculate ganglion exist in mutants. Tracing further showed that these geniculate ganglion neurons project exclusively to the solitary tract. In addition to the normal complement of facial branchial and visceral motoneurons, ngn1 null mutants have some trigeminal motoneurons and contralateral inner-ear efferents projecting, at least temporarily, through the facial nerve. These data suggest that some neurons in the brainstem (e.g., inner-ear efferents, trigeminal motoneurons) require afferents to grow along and redirect to ectopic cranial nerve roots in the absence of their corresponding sensory roots.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:34:25