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Titolo:
Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats
Autore:
Kohno, H; Yoshitani, S; Takashima, S; Okumura, A; Hosokawa, M; Yamaguchi, N; Tanaka, T;
Indirizzi:
Kanazawa Med Univ, Dept Pathol, Uchinada, Ishikawa 9200293, Japan KanazawaMed Univ Uchinada Ishikawa Japan 9200293 Ishikawa 9200293, Japan Kanazawa Med Univ, Dept Serol, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinada Ishikawa Japan 9200293 Ishikawa 9200293, Japan Kanazawa Med Univ, Dept Gen & Gastrointestinal Surg, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ Uchinada Ishikawa Japan 9200293 Ishikawa 9200293, Japan Anjo Kosei Hosp, Dept Endocrinol Metab, Anjo, Aichi 4468602, Japan Anjo Kosei Hosp Anjo Aichi Japan 4468602 etab, Anjo, Aichi 4468602, Japan Hokkaido Univ, Grad Sch Fisheries Sci, Hakodate, Hokkaido 0418611, Japan Hokkaido Univ Hakodate Hokkaido Japan 0418611 te, Hokkaido 0418611, Japan
Titolo Testata:
JAPANESE JOURNAL OF CANCER RESEARCH
fascicolo: 4, volume: 92, anno: 2001,
pagine: 396 - 403
SICI:
0910-5050(200104)92:4<396:TALFPP>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NITRIC-OXIDE SYNTHASE; HUMAN COLON-CANCER; PPAR-GAMMA; CELL-PROLIFERATION; TREFOIL PEPTIDES; REACTIVE OXYGEN; TUMOR PROMOTION; EXPRESSION; INFLAMMATION;
Keywords:
inhibition; colitis; aberrant crypt foci; PPAR gamma ligand; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Tanaka, T Kanazawa Med Univ, Dept Pathol, 1-1 Daigaku, Uchinada, Ishikawa 9200293, Japan Kanazawa Med Univ 1-1 Daigaku Uchinada Ishikawa Japan 9200293 an
Citazione:
H. Kohno et al., "Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats", JPN J CANC, 92(4), 2001, pp. 396-403

Abstract

The biological roles of peroxisome proliferator-activated receptors (PPARs) in various diseases, including inflammation and cancer, have been highlighted recently, Although PPAR gamma ligand is suspected to play an importantrole in carcinogenesis, its effects on colon tumorigenesis remain undetermined. The present time-course study was conducted to investigate possible modifying effects of a PPAR gamma ligand, troglitazone, on the development and growth of aberrant crypt foci (ACF), putative precursor lesions for colon carcinoma, induced by azoxymethane (AOM) or dextran sodium sulfate (DSS) in male F344 rats. Oral troglitazone (10 or 30 mg/kg body weight (b.w.)) significantly reduced AOM (two weekly subcutaneous injections, 20 mg/kg b.w.)-induced ACF, Treatment with troglitazone increased apoptosis and decreasedpolyamine content and ornithine decarboxylase (ODC) activity in the colonic mucosa of rats treated with AOM. Gastric gavage of troglitazone also inhibited colitis and ACF induced by DSS (1% in drinking water), in conjunctionwith increased apoptosis and reduced colonic mucosal polyamine level and ODC activity. Our results suggest that troglitazone, a synthetic PPAR gamma ligand, can inhibit the early stage of colon tumorigenesis with or without colitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:12:51