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Titolo:
Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium
Autore:
Yamamoto, T; Suto, N; Okubo, T; Mikuniya, A; Hanada, H; Yagihashi, S; Fujita, M; Okumura, K;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Internal Med 2, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Dept Pathol 1, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Kyoto Univ, Coll Med Technol, Kyoto 606, Japan Kyoto Univ Kyoto Japan 606 yoto Univ, Coll Med Technol, Kyoto 606, Japan
Titolo Testata:
JAPANESE CIRCULATION JOURNAL-ENGLISH EDITION
fascicolo: 5, volume: 65, anno: 2001,
pagine: 439 - 444
SICI:
0047-1828(200105)65:5<439:IDOBFG>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOGENESIS; DOGS; ISCHEMIA; MODEL;
Keywords:
angiogenesis; basic fibroblast growth factor; collateral circulation; myocardial blood flow; myocardial ischemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Okumura, K Hirosaki Univ, Sch Med, Dept Internal Med 2, 5 Zaifu Cho, Hirosaki, Aomori0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 , Japan
Citazione:
T. Yamamoto et al., "Intramyocardial delivery of basic fibroblast growth factor-impregnated gelatin hydrogel microspheres enhances collateral circulation to infarcted canine myocardium", JPN CIRC J, 65(5), 2001, pp. 439-444

Abstract

The present study examined whether basic fibroblast growth factor (bFGF)-impregnated acidic gelatin hydrogel microspheres (AGHM) would enhance collateral development to the infarct area in dogs with coronary occlusion. Studies were conducted in 28 jogs with a 2-week occlusion of the proximal left anterior descending coronary artery (LAD). The dogs were divided into a groups according to treatment: Group A treated with bFGF-impregnated AGHM in the infarct area; Group B with free-form bFGF; Group C with AGHM alone. Coronary angiography (n=15; Group A, 7 dogs; Group B, 5 dogs; Group C, 3 dogs) and a regional myocardial blood flow study (n=13; Group A, 6 dogs: Group B, 4 dogs; Group C, 3 dogs) were repeated at a 2-week interval. Coronary angiography revealed that in Group A, antegrade flow in the LAD distal to the occlusion, which was assessed by Thrombolysis in Myocardial Infarction (TIMI)grade, was significantly increased after treatment. In contrast, in GroupsB and C, the treatment did not change the how grade in the LAD. In Group 4, the regional myocardial blood how in the collateral dependent area was significantly increased after treatment, and the regional myocardial blood flow reserve after adenosine injection was also significantly increased. These measurements remained after treatment in Groups B and C, The immunohistochemical study with factor VIII-related antigen revealed an increase of vascular density in the ischemic region in Group A. Intramyocardial delivery ofbFGF-impregnated AGHM, but not free-form bFGF, improves the collateral circulation to the infarct area of a coronary occlusion in dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:53:27