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Titolo:
Oncogenic potential of human neurotropic virus: Laboratory and clinical observations
Autore:
Khalili, K; Croul, S; Del Valle, L; Krynska, B; Gordon, J;
Indirizzi:
Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, Philadelphia,PA 19122 USA Temple Univ Philadelphia PA USA 19122 anc Biol, Philadelphia,PA 19122 USA
Titolo Testata:
ISRAEL MEDICAL ASSOCIATION JOURNAL
fascicolo: 3, volume: 3, anno: 2001,
pagine: 210 - 215
SICI:
1565-1088(200103)3:3<210:OPOHNV>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; POLYOMAVIRUS JC-VIRUS; LARGE T-ANTIGENS; TRANSGENIC MICE; BRAIN-TUMORS; EARLY PROTEIN; DNA SEQUENCE; MEDULLOBLASTOMA; SUPPRESSOR; APOPTOSIS;
Keywords:
JC virus; T-antigen; medulloblastoma; oncogene; central nervous system;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Khalili, K Temple Univ, Coll Sci & Technol, Ctr Neurovirol & Canc Biol, 1900 N 12th St, Philadelphia, PA 19122 USA Temple Univ 1900 N 12th St Philadelphia PA USA 19122 19122 USA
Citazione:
K. Khalili et al., "Oncogenic potential of human neurotropic virus: Laboratory and clinical observations", ISR MED ASS, 3(3), 2001, pp. 210-215

Abstract

Cancer is a multi-step disease involving a series of genetic alterations that result in the loss of control of cell proliferation and differentiation. Such genetic alterations could emerge from the activation of oncogenes and the loss or malfunctioning of tumor suppressor gene activity, Our understanding of cancer has greatly increased through the use of DNA tumor Virusesand their transforming proteins as a biological tool to decipher a cascadeof events that lead to deregulation of cell proliferation and subsequent tumor formation. For the past ten years our laboratory has focused on the molecular biology of the human neurotropic papovavirus, JCV. This virus causes progressive multifocal leukoencephalopathy, a fatal neurodegenerative disease of the central nervous system in immunocompromised patients, JCV is a common human virus that infects more than 80% of humans but does not induceany obvious clinical symptoms. The increased incidence of acquired immune deficiency syndrome and the use of immunosuppressive chemotherapy have dramatically raised the incidence of PML. The coincidental occurrence of malignant astrocytes and oligodendrocytes in PML patients, coupled with the induction of glioblastoma in JCV-infected nonhuman primates, provides intriguingspeculation on the association between JCV and CNS malignancies. In this report we discuss clinical data and laboratory observations pointing to the direct involvement of JCV in cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:07:56