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Titolo:
Impaired fasting glycaemia in middle-aged women: a prospective study
Autore:
Guthrie, JR; Ball, M; Dudley, EC; Garamszegi, CV; Wahlqvist, ML; Dennerstein, L; Burger, HG;
Indirizzi:
Univ Melbourne, Off Gender & Hlth, RMH, Melbourne, Vic 3050, Australia Univ Melbourne Melbourne Vic Australia 3050 elbourne, Vic 3050, Australia Deakin Univ, Sch Biol & Chem Sci, Burwood, Vic, Australia Deakin Univ Burwood Vic Australia ol & Chem Sci, Burwood, Vic, Australia Monash Univ, Int Hlth & Dev Unit, Clayton, Vic 3168, Australia Monash Univ Clayton Vic Australia 3168 Unit, Clayton, Vic 3168, Australia Prince Henrys Inst Med Res, Clayton, Vic, Australia Prince Henrys Inst MedRes Clayton Vic Australia Clayton, Vic, Australia
Titolo Testata:
INTERNATIONAL JOURNAL OF OBESITY
fascicolo: 5, volume: 25, anno: 2001,
pagine: 646 - 651
SICI:
0307-0565(200105)25:5<646:IFGIMW>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DEPENDENT DIABETES-MELLITUS; RISK-FACTORS; MENOPAUSAL TRANSITION; GLUCOSE; POPULATION; ONSET;
Keywords:
impaired fasting glycaemia; menopausal transition; insulin; BMI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Guthrie, JR Univ Melbourne, Off Gender & Hlth, RMH, Charles Connibere Bldg, Melbourne,Vic 3050, Australia Univ Melbourne Charles Connibere Bldg Melbourne Vic Australia 3050
Citazione:
J.R. Guthrie et al., "Impaired fasting glycaemia in middle-aged women: a prospective study", INT J OBES, 25(5), 2001, pp. 646-651

Abstract

OBJECTIVES: To investigate: (i) the incidence of impaired fasting glycaemia (IFG) developed over 5y in a population-based sample of Australian-born women; (ii) prospectively the factors which are associated with the development of IFC; (iii) the association of the menopausal transition with the onset of IFC and an increase in serum insulin concentrations. DESIGN AND METHODS: A total of 265 women (110 pre-, 138 peri-, 17 postmenopausal) participants in the longitudinal phase of the Melbourne Women's Midlife Health Project, aged 46-57 and with normal fasting plasma glucose concentrations at the time of the initial measure, were interviewed, had physical measurements and blood taken annually over a 5y follow-up period. RESULTS: During the study period 43 women (16%) recorded a fasting glucoseconcentration of greater than or equal to6.1 mmol/l (IFG). Women who recorded IFG prospectively had, at the time of the initial measure when lasting glucose concentrations were normal: higher body mass index (BMI), trunk skinfold thicknesses, waist and hip circumferences (P < 0.005), lower SHBC, higher free androgen index and serum insulin concentrations (P < 0.05), higher systolic blood pressure, serum triglyceride and lower HDL-cholesterol concentrations (P < 0.05) than women whose fasting glucose concentrations remained normal. The onset of IFC was not triggered by the menopausal transition or hormone use. Changes in insulin concentration were associated with changes in BMI (P < 0.05). CONCLUSION: Women who developed IFC during the menopausal transition exhibited significantly higher levels of body fatness and dyslipidemia, premenopausally, compared with the women who did not develop IFC. The menopausal transition did not have an effect on the development of IFG, but weight gain during this period was associated with an increase in insulin concentration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 17:29:15