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Titolo:
Sensitivity of prefrontal cortex to changes in target probability: A functional MRI study
Autore:
Casey, BJ; Forman, SD; Franzen, P; Berkowitz, A; Braver, TS; Nystrom, LE; Thomas, KM; Noll, DC;
Indirizzi:
Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, New York, NY 10021 USA Cornell Univ New York NY USA 10021 Dev Psychobiol, New York, NY 10021 USA Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA ittsburgh, Med Ctr, Pittsburgh, PA USA Washington Univ, St Louis, MO USA Washington Univ St Louis MO USAWashington Univ, St Louis, MO USA Princeton Univ, Princeton, NJ 08544 USA Princeton Univ Princeton NJ USA 08544 ceton Univ, Princeton, NJ 08544 USA Univ Michigan, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 iv Michigan, Ann Arbor, MI 48109 USA
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 1, volume: 13, anno: 2001,
pagine: 26 - 33
SICI:
1065-9471(200105)13:1<26:SOPCTC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPATIAL WORKING-MEMORY; ACTIVATION; PET; TASK; CONTEXT; MONKEYS;
Keywords:
prefrontal cortex; attention; inhibition; neuroimaging; fMRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Casey, BJ Cornell Univ, Weill Med Coll, Sackler Inst Dev Psychobiol, 1300 York Ave,Box 140, New York, NY 10021 USA Cornell Univ 1300 York Ave,Box 140New York NY USA 10021 021 USA
Citazione:
B.J. Casey et al., "Sensitivity of prefrontal cortex to changes in target probability: A functional MRI study", HUM BRAIN M, 13(1), 2001, pp. 26-33

Abstract

Electrophysiological studies suggest sensitivity of the prefrontal cortex to changes in the probability of an event. The purpose of this study was todetermine if subregions of the prefrontal cortex respond differentially tochanges in target probabilities using functional magnetic resonance imaging (fMRI). Ten right-handed adults were scanned using a gradient-echo, echo planar imaging sequence during performance of an oddball paradigm. Subjectswere instructed to respond to any letter but "X". The frequency of targets(i.e., any letter but X) varied across trials. The results showed that dorsal prefrontal regions were active during infrequent events and ventral prefrontal regions were active during frequent events. Further, we observed aninverse relation between the dorsal and ventral prefrontal regions such that when activity in dorsal prefrontal regions increased, activity in ventral prefrontal regions decreased, and vice versa. This finding may index competing cognitive processes or capacity limitations. Most importantly, these findings taken as a whole suggest that any simple theory of prefrontal cortex function must take into account the sensitivity of this region to changes in target probability. Hum. Brain Mapping 13:26-33, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 10:01:25