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Titolo:
The protective effect of taurine against thioacetamide hepatotoxicity of rats
Autore:
Dogru-Abbasoglu, S; Kanbagli, O; Balkan, J; Cevikbas, U; Aykac-Toker, G; Uysal, M;
Indirizzi:
Univ Istanbul, Istanbul Fac Med, Dept Biochem, TR-34390 Istanbul, Turkey Univ Istanbul Istanbul Turkey TR-34390 iochem, TR-34390 Istanbul, Turkey Univ Istanbul, Istanbul Fac Med, Dept Pathol, TR-34390 Istanbul, Turkey Univ Istanbul Istanbul Turkey TR-34390 Pathol, TR-34390 Istanbul, Turkey
Titolo Testata:
HUMAN & EXPERIMENTAL TOXICOLOGY
fascicolo: 1, volume: 20, anno: 2001,
pagine: 23 - 27
SICI:
0960-3271(200101)20:1<23:TPEOTA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED HEPATIC STEATOSIS; HIGH-CHOLESTEROL DIET; LIPID-PEROXIDATION; LIVER CHOLESTEROL; ANIMAL-TISSUES; VITAMIN-E; TOXICITY; PLASMA; SERUM; MICE;
Keywords:
taurine; thioacetamide; lipid peroxidation; antioxidants; liver;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Dogru-Abbasoglu, S Univ Istanbul, Istanbul Fac Med, Dept Biochem, TR-34390Istanbul, Turkey Univ Istanbul Istanbul Turkey TR-34390 tanbul, Turkey
Citazione:
S. Dogru-Abbasoglu et al., "The protective effect of taurine against thioacetamide hepatotoxicity of rats", HUM EXP TOX, 20(1), 2001, pp. 23-27

Abstract

Thioacetamide (TAA) administration (three consecutive intraperitoneal injections of 400 mg/kg at 24-h interval) to rats resulted in hepatic injury asassessed by the measurement of serum transaminase activities and histopathological findings. This treatment caused an increase in the levels of malondialdehyde (MDA), diene conjugates (DCs) and glutathione (GSH) and the activity of superoxide dismutase (SOD), and a decrease in the levels of vitamins E and C and the activity of glutathione peroxidase (GSH-Px) in the liver of rats. Taurine administration (400 mg/kg, i.p., every 12 h and started 24h prior to the first TAA injection) was found to decrease serum transaminase activities and hepatic lipid peroxidation without any significant changein hepatic antioxidant system. Histopathological findings also suggested that taurine has ameliorated effect on TAA-induced hepatic necrosis. These results indicate that taurine treatment, together with TAA administration, diminished the severity of the liver injury by decreasing oxidative stress due to its possible scavenger effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 23:27:00