Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dorsal/ventral hippocampus, fornix, and conditioned place preference
Autore:
Ferbinteanu, J; McDonald, RJ;
Indirizzi:
Univ Toronto, Dept Psychol, Toronto, ON M5S 1A1, Canada Univ Toronto Toronto ON Canada M5S 1A1 ychol, Toronto, ON M5S 1A1, Canada
Titolo Testata:
HIPPOCAMPUS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 187 - 200
SICI:
1050-9631(2001)11:2<187:DHFACP>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; FIMBRIA-FORNIX; DORSAL STRIATUM; AMYGDALOID PROJECTIONS; VENTRAL HIPPOCAMPUS; LOCOMOTOR-ACTIVITY; IBOTENATE LESIONS; MEMORY DEFICITS; WATER MAZE; RATS;
Keywords:
amygdala; fornix; spatial; relational; configural; stimulus-reward association;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Ferbinteanu, J CUNY Mt Sinai Sch Med, Dept Neurobiol, 1 Gustave Levy Pl, New York, NY 10029 USA CUNY Mt Sinai Sch Med 1 Gustave Levy Pl New York NY USA 10029
Citazione:
J. Ferbinteanu e R.J. McDonald, "Dorsal/ventral hippocampus, fornix, and conditioned place preference", HIPPOCAMPUS, 11(2), 2001, pp. 187-200

Abstract

Conditioned place preference (CPP) is a learning paradigm requiring formation of associations between reward and particular locations. White and McDonald (Behav Brain Res 1993;55:269-281) demonstrated that amygdala (AMG) lesions impair, while fornix (Fx) lesions enhance learning of this task. In the present experiments, we replicated the effects of AMG and Fx lesions, butwe also found that complete hippocampal (HPC) lesions interfere with normal performance. Thus, the effects of Fx and HPC lesions on CPP are opposite. This is in contrast with spatial learning in the water maze. Because it has been demonstrated that damage of dorsal HPC interferes to a greater extent with spatial learning than damage of ventral HPC, we also tested animals with either dorsal or ventral HPC disruptions on CPP. Lesions limited to dorsal HPC were followed by impairment on this task. In contrast, lesions limited to ventral HPC resulted in enhanced learning. We argue that Fx and HPClesions do not have interchangeable effects in all learning paradigms. To explain the complex pattern of results presently obtained, we propose a novel hypothesis regarding behavioral functions of HPC neural circuits. Implications regarding the interaction between memory systems are also considered. Hippocampus 2001;11:187-200. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 19:05:52