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Titolo:
Activation of the dentate gyrus by stimulation of the contralateral perforant pathway: Evoked potentials and long-term potentiation after ipsi- and contralateral induction
Autore:
Krug, M; Brodemann, R; Matthies, R; Ruthrich, H; Wagner, M;
Indirizzi:
Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, D-39120 Magdeburg, Germany Otto Von Guericke Univ Magdeburg Germany D-39120 9120 Magdeburg, Germany
Titolo Testata:
HIPPOCAMPUS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 157 - 167
SICI:
1050-9631(2001)11:2<157:AOTDGB>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIPPOCAMPAL CA1 REGION; FREELY MOVING RATS; ENTORHINAL LESIONS; PROTEIN-SYNTHESIS; IN-VIVO; MEMORY; ORGANIZATION; SYNAPSES; LTP; MAINTENANCE;
Keywords:
dentate gyrus; evoked field potentials; entorhinal cortex; freely moving rat; LTP; paired-pulse stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Krug, M Otto Von Guericke Univ, Fac Med, Inst Pharmacol & Toxicol, Leipziger Str 44, D-39120 Magdeburg, Germany Otto Von Guericke Univ Leipziger Str 44 Magdeburg Germany D-39120
Citazione:
M. Krug et al., "Activation of the dentate gyrus by stimulation of the contralateral perforant pathway: Evoked potentials and long-term potentiation after ipsi- and contralateral induction", HIPPOCAMPUS, 11(2), 2001, pp. 157-167

Abstract

Rats were chronically implanted with stimulation electrodes in the perforant pathway (pp) bilaterally and a recording electrode in the dentate gyrus (DC) unilaterally. Evoked field potentials (EPs) were recorded upon alternating stimulation of the pp on both sides, and longterm potentiation (LTP) was induced. Besides the EP after ipsilateral stimulation, an EP with a latency of approximately 5.5-6.5 ms was also seen upon stimulation of the contralateral pp. This potential was reversibly abolished during pentobarbital anesthesia and irreversibly after lesioning of the ipsilateral angular bundle. Paired-pulse facilitation and paired-pulse depression, depending on interstimulus interval and intensity, were also observed. Therefore, this long-latency potential could be characterized as polysynaptic and induced perhaps by transsynaptic activation via the ipsilateral entorhinal cortex. Ipsilateral tetanization induced strong E/S potentiation of both the ipsilaterally and contralaterally evoked EP, but with different time courses. Tetanization of the contralateral pp did not induce LTP of the ipsilaterally inducedEP in the first 4 h. But afterwards a late and slowly developing potentiation occurred. The contralaterally induced EP also showed potentiation of the population spike, which was not immediately detectable but developed slowly over time. The results can be interpreted such that, after stimulation of the pp, the DC on the opposite side cannot only be activated via the weakcrossed entorhinal projection but also transsynaptically via an entorhino/entorhinal connection. Hippocampos 2001;11:157-167. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:22:14