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Titolo:
Spatial and temporal patterns of morphogenesis of hippocampal pyramidal cells: Study in the early postnatal rat
Autore:
Lopez-Gallardo, M; Prada, C;
Indirizzi:
Univ Complutense Madrid, Fac Med, Dept Fisiol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 siol, E-28040 Madrid, Spain
Titolo Testata:
HIPPOCAMPUS
fascicolo: 2, volume: 11, anno: 2001,
pagine: 118 - 131
SICI:
1050-9631(2001)11:2<118:SATPOM>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOSSY FIBERS; CHICK RETINA; NEURONS; CULTURE; GOLGI; NEUROGENESIS; EXCRESCENCES; POLARITY; REGION; AREA;
Keywords:
dendrititic differentiation; soma shape differentiation; spatial gradients;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Prada, C Univ Complutense Madrid, Fac Med, Dept Fisiol, Ciudad Univ S-N, E-28040 Madrid, Spain Univ Complutense Madrid Ciudad Univ S-N Madrid Spain E-28040 ain
Citazione:
M. Lopez-Gallardo e C. Prada, "Spatial and temporal patterns of morphogenesis of hippocampal pyramidal cells: Study in the early postnatal rat", HIPPOCAMPUS, 11(2), 2001, pp. 118-131

Abstract

Several studies have dealt with the morphogenesis of the rat hippocampal pyramidal cell, but little is known about how the different pyramidal cell shapes of CA fields differentiate from neuroepithelial cells, or about how the field morphological identity emerges. From our studies of pyramidal cellshapes in the CA1, CA3, and CA4 fields of hippocampi at postnatal developmental stages between P0 and P12, using fresh semidissociated slices and acutely dissociated cells, we identified the sequence of cell shape transformation by which they differentiate from simple bipolar to complex shapes characteristic of adult pyramidal cells of CA1 and CA3. Pyramidal cell morphogenesis does not occur synchronously throughout the CA hippocampus fields, but cells in the CA4 field undergo morphological differentiation at earlier stages, prenatally, than CA3 cells, and these in turn earlier than CA1 cells. Thus, during the P1-P6 stages, a gradient of shapes from less to greater differentiation was clearly observed from CA1 to CA4 in a single slice. Furthermore, a mixture of cells at different degrees of differentiation is observed in CA1 from P1 to P10, and in CA3 from P1 to P5. A gradient of shapesfrom more to less differentiation was observed at stages P5-P6 from septalto temporal. We describe two processes in the pyramidal cell morphogenesisin the CA1 and CA3 fields, the approximation to the soma of the point of bifurcation of the main apical process, and the acquisition of triangular shape of the soma, showing by a quantitative study of both processes that they occur earlier in CA3 than in CA1. Our study, therefore, provides new insight into rat pyramidal cell morphogenesis, and indicates that this process might be differently regulated in the various CA fields. Hippocampos 2001;11:718-131. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:34:49