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Titolo:
Two-staged treatment with local resection and percutaneous isolated hepatic chemoperfusion for advanced pancreatic cancer with multiple liver metastases: Report of a case
Autore:
Suzuki, Y; Ku, Y; Tominaga, M; Kamigaki, T; Fujino, Y; Tanioka, Y; Iwasaki, T; Fukumoto, T; Takeyama, Y; Kuroda, Y;
Indirizzi:
Kobe Univ, Sch Med, Dept Surg 1, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 1, Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
HEPATO-GASTROENTEROLOGY
fascicolo: 38, volume: 48, anno: 2001,
pagine: 574 - 577
SICI:
0172-6390(200103/04)48:38<574:TTWLRA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXTRACORPOREAL CHARCOAL HEMOPERFUSION; INTRAOPERATIVE RADIATION-THERAPY; DISTAL PANCREATECTOMY; ULTRASONIC DISSECTOR; VENOUS ISOLATION; ADENOCARCINOMA; CHEMOTHERAPY; CARCINOMA;
Keywords:
pancreatic cancer; liver metastasis; percutaneous isolated hepatic chemoperfusion (PIHP);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, Y Kobe Univ, Sch Med, Dept Surg 1, Chuo Ku, 7-5-2 Kusunoki Cho, Kobe, Hyogo 6500017, Japan Kobe Univ 7-5-2 Kusunoki Cho Kobe Hyogo Japan 6500017 017, Japan
Citazione:
Y. Suzuki et al., "Two-staged treatment with local resection and percutaneous isolated hepatic chemoperfusion for advanced pancreatic cancer with multiple liver metastases: Report of a case", HEP-GASTRO, 48(38), 2001, pp. 574-577

Abstract

There have been disappointingly few effective treatment modalities for multiple liver metastases from pancreatic cancer. Percutaneous isolated hepatic perfusion, which was developed by us for delivering dose-intensive chemotherapy to the liver, has a high efficacy in the majority of patients with multiple primary and secondary liver tumors. We herein report the first experience of a two-stage treatment with extended local resection and subsequent two percutaneous isolated hepatic perfusions for advanced pancreatic ductal adenocarcinoma with liver metastases. The second percutaneous isolated hepatic per fusion with high-dose cisplatin and mitomycin C demonstrated a distinct regression of metastatic liver tumors. Although a long-term patientsurvival was not obtained due to local recurrence, liver metastases have been well controlled ever since. Given that further studies establish the efficacy of percutaneous isolated hepatic perfusion also in this field, this modality would be used as prophylaxis as well as treatment of liver metastasis in patients with advanced pancreatic ductal adenocarcinoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:19:52