Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Maternal and paternal family history of diabetes in women with gestationaldiabetes or insulin-dependent diabetes mellitus type I
Autore:
Harder, T; Franke, K; Kohlhoff, R; Plagemann, A;
Indirizzi:
Humboldt Univ, Inst Expt Endocrinol, Med Sch Charite, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 ch Charite, D-10098 Berlin, Germany Clin Obstet & Gynaecol, Berlin, Germany Clin Obstet & Gynaecol Berlin Germany bstet & Gynaecol, Berlin, Germany
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
fascicolo: 3, volume: 51, anno: 2001,
pagine: 160 - 164
SICI:
0378-7346(2001)51:3<160:MAPFHO>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOSE-TOLERANCE; RISK; MOTHERS; IDDM; HYPERINSULINISM; TRANSMISSION; AGGREGATION; PREGNANCY; REGISTRY; RATS;
Keywords:
non-insulin-dependent diabetes mellitus; insulin-dependent diabetes mellitus; gestational diabetes; epigenetic transmission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Plagemann, A Humboldt Univ, Inst Expt Endocrinol, Med Sch Charite, Schumannstr 20-21, D-10098 Berlin, Germany Humboldt Univ Schumannstr 20-21 BerlinGermany D-10098 rmany
Citazione:
T. Harder et al., "Maternal and paternal family history of diabetes in women with gestationaldiabetes or insulin-dependent diabetes mellitus type I", GYNECOL OBS, 51(3), 2001, pp. 160-164

Abstract

Animal studies have shown that prenatal exposure to a diabetic intrauterine milieu leads to an increased risk in the female offspring of developing gestational diabetes IGD). In the present study, the family history of non-insulin-dependent diabetes mellitus type II (NIDDM) and insulin-dependent diabetes mellitus type I (IDDM) was evaluated in 106 women with GD, as compared to 189 women with IDDM. In GD patients, the prevalence of diabetes was significantly greater in mothers than in fathers (p = 0.03). This was mainlydue to a greater prevalence of NIDDM in the mothers (p = 0.05). Furthermore, a significant aggregation of NIDDM was also observed in the maternal-grandmaternal line of GD women, as compared to the paternal-grandpaternal side(p = 0.02). In patients with IDDM no significant difference concerning theprevalence of any type of diabetes between mothers and fathers was observed. In conclusion, an aggregation of NIDDM in mothers and grandmothers of women with GD is reported here. A history of NIDDM on the maternal side of pregnant women should be considered as a particular risk factor for GD and, hence, for intergenerative transmission of NIDDM which therefore might be prevented, at least in part, by strict avoidance of GD. Copyright (C) 2001 S. KargerAG, Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:48:15