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Titolo:
Low frequency of HLA-DRBI*11 in hepatitis C virus induced end stage liver disease
Autore:
Tillmann, HL; Chen, DF; Trautwein, C; Kliem, V; Grundey, A; Berning-Haag, A; Boker, K; Kubicka, S; Pastucha, L; Stangel, W; Manns, MP;
Indirizzi:
Med Hsch Hannover, Dept Gastroenterol & Hepatol, D-30625 Hannover, GermanyMed Hsch Hannover Hannover Germany D-30625 ol, D-30625 Hannover, Germany Med Hsch Hannover, Dept Transfus Med, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 ed, D-30625 Hannover, Germany Med Hsch Hannover, Dept Nephrol, D-30625 Hannover, Germany Med Hsch Hannover Hannover Germany D-30625 ol, D-30625 Hannover, Germany Ctr Blood Res, HLA Lab, Boston, MA 02115 USA Ctr Blood Res Boston MA USA 02115 lood Res, HLA Lab, Boston, MA 02115 USA
Titolo Testata:
GUT
fascicolo: 5, volume: 48, anno: 2001,
pagine: 714 - 718
SICI:
0017-5749(200105)48:5<714:LFOHIH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; ANTI-D IMMUNOGLOBULIN; CLASS-II GENOTYPE; VIRAL CLEARANCE; HLA ANTIGENS; RNA LEVELS; B VIRUS; INFECTION; ASSOCIATION; ALLELES;
Keywords:
hepatitis C; HLA; liver cirrhosis; immunogenetics; hepatocellular carcinoma; genotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Manns, MP Med Hsch Hannover, Dept Gastroenterol & Hepatol, Carl Neuberg Str 1, D-30625 Hannover, Germany Med Hsch Hannover Carl Neuberg Str 1 Hannover Germany D-30625 y
Citazione:
H.L. Tillmann et al., "Low frequency of HLA-DRBI*11 in hepatitis C virus induced end stage liver disease", GUT, 48(5), 2001, pp. 714-718

Abstract

Hepatitis C virus (HCV) infection becomes chronic in more than 70% of patients, leading to endstage liver disease in about 20-30% of these patients. Apart from the virus itself,host factors that modulate the immune response are likely to be involved in determining the outcome of HCV infection. Studies on the association of human leucocyte antigens (HLAs) and HCV infectionhave shown inconsistent results. Selection of patient subgroups may be crucial. However, any association relevant to HCV disease progression will become evident, especially in those patients with end stage liver disease. Therefore, we analysed the phenotype frequencies of HLA antigens in two groupsof 69 and 39 patients with HCV induced liver cirrhosis who had received a transplant or were awaiting liver transplantation, The first group was typed serologically and compared with 331 blood and Liver donors. The second; group, prospectively HLA typed by a polymerase chain reaction-sequence specific oligonucleotide (PCR-SSO) procedure for HLA-DRB and DQB alleles, was compared with another 170 PCR-SSO typed and randomly selected blood donors. Decreased frequencies for HLA-DR5 and HLA-DQ3 were found in one group of patients with HCV induced liver cirrhosis compared with the control groups. Inthe second analysis comparing 39 patients with end stage liver cirrhosis with blood donors, we confirmed the significant decrease in HLA-DRB1*11 and HLA-DQB1*03, which corresponded to serological HLA-DR5 and HLA-DQ3 antigens, respectively. Our results show that the presence of HLA-DRB1*11 and HLA-DQB1*03 alleles is associated with a reduced risk for the development of HCVinduced end stage liver disease.

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Documento generato il 04/04/20 alle ore 12:29:09