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Titolo:
Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) - an effective route of antifungal vaccine preparation
Autore:
Bystricky, S; Machova, E; Bartek, P; Kolarova, N; Kogan, G;
Indirizzi:
Slovak Acad Sci, Inst Chem, Bratislava 84238, Slovakia Slovak Acad Sci Bratislava Slovakia 84238 em, Bratislava 84238, Slovakia
Titolo Testata:
GLYCOCONJUGATE JOURNAL
fascicolo: 10, volume: 17, anno: 2000,
pagine: 677 - 680
SICI:
0282-0080(200010)17:10<677:COYMWP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOLOGICAL PROPERTIES; 1-CYANO-4-DIMETHYLAMINOPYRIDINIUM TETRAFLUOROBORATE; SOLUBLE POLYSACCHARIDES; CANDIDA-ALBICANS; CROSS-LINKING; SEROTYPE-A; ACTIVATION; REAGENTS; MICE;
Keywords:
mannan conjugate; galactoglucoxylomannan conjugate; CDAP; antifungal vaccine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Bystricky, S Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, Bratislava 84238, Slovakia Slovak Acad Sci Dubravska Cesta 9 Bratislava Slovakia 84238
Citazione:
S. Bystricky et al., "Conjugation of yeast mannans with protein employing cyanopyridinium agent (CDAP) - an effective route of antifungal vaccine preparation", GLYCOCON J, 17(10), 2000, pp. 677-680

Abstract

The possibility of using 1-cyano-4-dimethylaminopyridinium tetrafluoroborate (CDAP) for activation of saccharide hydroxyl groups (instead of hazardous cyanogen bromide) is examined with cell-surface mannans of the yeasts Candida albicans,Candida tropicalis, Candida lambica and galactoglucoxylomannan of Cryptococcus laurentii. Direct conjugation with human serum albumin yielded soluble products with increased molecular size in comparison with theoriginal polysaccharides. Immunodiffusion experiments revealed that conjugation did not affect the immunospecificity of the antigen epitope.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:54:19