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Titolo:
The NF2 tumor suppressor gene product, merlin, mediates contact inhibitionof growth through interactions with CD44
Autore:
Morrison, H; Sherman, LS; Legg, J; Banine, F; Isacke, G; Haipek, CA; Gutmann, DH; Ponta, H; Herrlich, P;
Indirizzi:
Forschungszentrum Karlsruhe, Inst Genet & Toxikol, D-76021 Karlsruhe, Germany Forschungszentrum Karlsruhe Karlsruhe Germany D-76021 Karlsruhe, Germany Univ Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany Univ Karlsruhe Karlsruhe Germany D-76021 net, D-76021 Karlsruhe, Germany Univ Cincinnati, Coll Med, Dept Cell Biol Neurobiol & Anat, Cincinnati, OH45267 USA Univ Cincinnati Cincinnati OH USA 45267 l & Anat, Cincinnati, OH45267 USA Univ London Imperial Coll Sci Technol & Med, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med London England SW7 2AZ gland Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA Washington Univ St Louis MO USA 63110 Dept Neurol, St Louis, MO 63110 USA
Titolo Testata:
GENES & DEVELOPMENT
fascicolo: 8, volume: 15, anno: 2001,
pagine: 968 - 980
SICI:
0890-9369(20010415)15:8<968:TNTSGP>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EZRIN/RADIXIN/MOESIN ERM PROTEINS; NEUROFIBROMATOSIS TYPE-2 PATIENTS; PLASMA-MEMBRANE; DEPENDENT INHIBITION; MAMMALIAN-CELLS; SCHWANN-CELLS; DNA-SYNTHESIS; BINDING-SITE; F-ACTIN; EZRIN;
Keywords:
NF2; CD44; ezrin; hyaluronate; ERM; Schwann cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Herrlich, P Forschungszentrum Karlsruhe, Inst Genet & Toxikol, D-76021 Karlsruhe, Germany Forschungszentrum Karlsruhe Karlsruhe Germany D-76021 ermany
Citazione:
H. Morrison et al., "The NF2 tumor suppressor gene product, merlin, mediates contact inhibitionof growth through interactions with CD44", GENE DEV, 15(8), 2001, pp. 968-980

Abstract

The neurofibromatosis-2 (NF2) gene encodes merlin, an ezrin-radixin-moesin-(ERM)-related protein that functions as a tumor suppressor. We found that merlin mediates contact inhibition of growth through signals from the extracellular matrix. At high cell density, merlin becomes hypo-phosphorylated and inhibits cell growth in response to hyaluronate (HA), a mucopolysaccharide that surrounds cells. Merlin's growth-inhibitory activity depends on specific interaction with the cytoplasmic tail of CD44, a transmembrane HA receptor. At lear cell density, merlin is phosphorylated, growth permissive, and exists in a complex with ezrin, moesin, and CD44. These data indicate that merlin and CD44 form a molecular switch that specifies cell growth arrest or proliferation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:59:50