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Titolo:
Gene therapy effectiveness differs for neuronal survival and behavioral performance
Autore:
Phillips, RG; Monje, ML; Giuli, LC; Meier, TJ; Yenari, MA; Kunis, D; Sapolsky, RM;
Indirizzi:
Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Dept Biol Sci, Stanford, CA 94305 USA
Titolo Testata:
GENE THERAPY
fascicolo: 8, volume: 8, anno: 2001,
pagine: 579 - 585
SICI:
0969-7128(200104)8:8<579:GTEDFN>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CALBINDIN D-28K; RAT HIPPOCAMPUS; IN-VIVO; CALCIUM; EXPRESSION; GLUTAMATE; NEUROTOXICITY; MECHANISMS; PROTECT; STRESS;
Keywords:
calbindin; gene transfer; neurodegeneration; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Sapolsky, RM Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA StanfordUniv Stanford CA USA 94305 , Stanford, CA 94305 USA
Citazione:
R.G. Phillips et al., "Gene therapy effectiveness differs for neuronal survival and behavioral performance", GENE THER, 8(8), 2001, pp. 579-585

Abstract

If neuronal gene therapy is to be clinically useful, it is necessary to demonstrate neuroprotection when the gene is introduced after insult. We now report equivalent neuronal protection if calbindin D-28K gene transfer via herpes simplex virus amplicon vector occurs immediately, 30 min, or Ih after an excitotoxic insult, but not after a 4h delay. Behavioral performance was evaluated for immediate and Ih delay groups using a hippocampal-dependent task. Despite equivalent magnitude and pattern of sparing of neurons withthe immediate and 1 h delay approaches, the delay animals took a significantly longer time after insult to return to normal performance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 07:19:08