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Titolo:
FDG-PET imaging for the staging and follow-up of small cell lung cancer
Autore:
Schumacher, T; Brink, I; Mix, M; Reinhardt, R; Herget, G; Digel, W; Henke, M; Moser, E; Nitzsche, E;
Indirizzi:
Univ Freiburg, Med Ctr, Div Nucl Med, Freiburg, Germany Univ Freiburg Freiburg Germany Med Ctr, Div Nucl Med, Freiburg, Germany Univ Freiburg, Med Ctr, Div Thorac Surg, Freiburg, Germany Univ Freiburg Freiburg Germany Ctr, Div Thorac Surg, Freiburg, Germany Univ Freiburg, Med Ctr, Div Hematol & Oncol, Freiburg, Germany Univ Freiburg Freiburg Germany , Div Hematol & Oncol, Freiburg, Germany Univ Freiburg, Med Ctr, Div Radiotherapy, Freiburg, Germany Univ FreiburgFreiburg Germany Ctr, Div Radiotherapy, Freiburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 4, volume: 28, anno: 2001,
pagine: 483 - 488
SICI:
0340-6997(200104)28:4<483:FIFTSA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; WHOLE-BODY PET; BRONCHOGENIC-CARCINOMA; COST-EFFECTIVENESS; LYMPH-NODES; CT; METASTASES; CISPLATIN; ETOPOSIDE;
Keywords:
small cell lung cancer; fluorine-18 fluorodeoxyglucose; positron emission tomography; cancer imaging; radionuclide imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Schumacher, T Univ Basel, Kantonsspital, Med Ctr, Dept Radiol Sci,Div NuclMed, Petersgraben 04, CH-4031 Basel, Switzerland Univ Basel Petersgraben 04 Basel Switzerland CH-4031 erland
Citazione:
T. Schumacher et al., "FDG-PET imaging for the staging and follow-up of small cell lung cancer", EUR J NUCL, 28(4), 2001, pp. 483-488

Abstract

The staging procedures for small cell lung cancer do not differ appreciably from those for other forms of lung cancer. For practical pul poses, the TNM stages are usually collapsed into a simple binary classification: limited disease and extensive disease. This study was performed to answer the question of whether fluorine-18 labelled 2-deoxy-2-D-glucose positron emissiontomography (FDG-PET) imaging permits appropriate work-up (including both primary and follow-up staging) of patients presenting with small cell lung cancer, as compared with currently recommended staging procedures. Thirty-six FDG-PET examinations were performed in 30 patients with histologically proven small cell lung cancer. Twenty-four patients were examined for primarystaging while four were imaged for therapy follow-up only. Two patients underwent both primary staging and up to four examinations for therapy follow-up. Static PET imaging was performed according to a standard protocol. Image reconstruction was based on an ordered subset expectation maximization algorithm including post-injection segmented attenuation correction. Resultsof FDG-PET were compared with those of the sum of other staging procedures. Identical results from FDG-PET and the sum of the other staging procedures were obtained in 23 of 36 examinations (6x limited disease, 12x extensivedisease, 5x no evidence of disease). In contrast to the results of conventional staging, FDG-PET indicated extensive disease resulting in an up-staging in seven patients. Tn one patient in whom there was no evidence for tumour on conventional investigations following treatment, FDG-PET was suggestive of residual viability of the primary tumour. Furthermore, discordant results were observed in five patients with respect to lung, bone, liver and adrenal gland findings, although in these cases the results did not affect staging as limited or extensive disease. Moreover, FDG-PET appeared to be more sensitive for the detection of metastatic mediastinal and hilar lymph nodes and bone metastases. Finally, all findings considered suspicious for tumour involvement on the other staging procedures were also detected by FDG-PET. It is concluded that FDG-PET has potential for use as a simplified staging tool for small cell lung cancer.

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Documento generato il 06/04/20 alle ore 01:35:49