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Titolo:
Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data
Autore:
Kalliokoski, KK; Kuusela, TA; Nuutila, P; Tolvanen, T; Oikonen, V; Teras, M; Takala, TES; Knuuti, J;
Indirizzi:
Univ Turku, Turku PET Ctr, Turku 20520, Finland Univ Turku Turku Finland20520 urku, Turku PET Ctr, Turku 20520, Finland Univ Turku, Dept Med, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Med, Turku, Finland Univ Turku, Dept Appl Phys, Turku, Finland Univ Turku Turku FinlandUniv Turku, Dept Appl Phys, Turku, Finland Univ Jyvaskyla, Dept Biol Phys Activ, SF-40100 Jyvaskyla, Finland Univ Jyvaskyla Jyvaskyla Finland SF-40100 v, SF-40100 Jyvaskyla, Finland
Titolo Testata:
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
fascicolo: 4, volume: 28, anno: 2001,
pagine: 450 - 456
SICI:
0340-6997(200104)28:4<450:PHIHSM>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; IMAGE-RECONSTRUCTION; GLUCOSE-UPTAKE; STIMULATION; EXERCISE; INSULIN; PATTERNS; RABBIT; REST;
Keywords:
perfusion; fractal analysis; positron emission tomography; skeletal muscle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kalliokoski, KK Univ Turku, Turku PET Ctr, Kiinamyllynkatu 4-8, Turku 20520, Finland Univ Turku Kiinamyllynkatu 4-8 Turku Finland 20520 inland
Citazione:
K.K. Kalliokoski et al., "Perfusion heterogeneity in human skeletal muscle: fractal analysis of PET data", EUR J NUCL, 28(4), 2001, pp. 450-456

Abstract

Muscle blood flow has been shown to be heterogeneous at the voxel by voxellevel in positron emission tomography (PET) studies using oxygen-15 labelled water. However, the limited spatial resolution of the imaging device does not allow direct measurement of true vascular flow heterogeneity. Fractaldimension (D) obtained by fractal analysis describes the relationship between the relative dispersion and the size of the region studied, and has been used for the assessment of perfusion heterogeneity in microvascular units. This study was undertaken to evaluate fractal characteristics of PET perfusion data and to estimate perfusion heterogeneity in microvascular units. Skeletal muscle blood flow was measured in healthy subjects using [O-15]water PET and the fractal characteristics of blood flow in resting and exercising skeletal muscle were analysed. The perfusion heterogeneity in microvascular units was estimated using the measured heterogeneity (relative dispersion, RD= SD/mean) and D values. Heterogeneity due to methodological factorswas estimated with phantoms and subtracted from the flow data. The number of aggregated voxels was inversely correlated with RD both in phantoms (Pearson r=-0.96-0.97) and in muscle (Pearson r=-0.94) when both parameters were expressed using a logarithmic scale. Fractal dimension was similar between exercising (1.13) and resting (1.14) muscles and significantly lower thanthe values in the phantoms with different activity levels (1.27-1.29). Measured flow heterogeneity values were 20%+/-6% (exercise) and 27%+/-5% (rest, P<0.001), whereas estimated flow heterogeneity values in microvascular units (1 mm(3)) were 35%+/-14% (exercise) and 49%+/-14% (rest, P<0.01). In conclusion, these results show that it is feasible to apply fractal analysis to PET perfusion data. When microvascular flow heterogeneity is estimated using fractals, perfusion appears to be more heterogeneous in microvascular units than when obtained by routine spatial analysis of PET data. Analysis of flow heterogeneity using PET and fractals could provide new insight intophysiological conditions and diseases associated with changes in peripheral vascular function.

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Documento generato il 19/01/20 alle ore 06:20:50