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Titolo:
Regulation of SSAT expression by synaptic activity
Autore:
Ingi, T; Worley, PF; Lanahan, AA;
Indirizzi:
Niigata Univ, Brain Res Inst, Dept Neurophysiol, Niigata 9518585, Japan Niigata Univ Niigata Japan 9518585 Neurophysiol, Niigata 9518585, Japan Johns Hopkins Univ, Sch Med, Dept Neurosci & Neurol, Baltimore, MD 21210 USA Johns Hopkins Univ Baltimore MD USA 21210 Neurol, Baltimore, MD 21210 USA
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 13, anno: 2001,
pagine: 1459 - 1463
SICI:
0953-816X(200104)13:7<1459:ROSEBS>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; LONG-TERM ENHANCEMENT; IMMEDIATE-EARLY GENES; SPERMIDINE/SPERMINE N-1-ACETYLTRANSFERASE; GLUTAMATE RECEPTORS; MESSENGER-RNAS; CHANNEL BLOCK; RAT-BRAIN; C-FOS; TRANSCRIPTION;
Keywords:
development; hippocampus; long-term potentiation; plasticity; rat; SSAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Ingi, T Niigata Univ, Brain Res Inst, Dept Neurophysiol, 1 Asahi Machi, Niigata 9518585, Japan Niigata Univ 1 Asahi Machi Niigata Japan 9518585 a 9518585, Japan
Citazione:
T. Ingi et al., "Regulation of SSAT expression by synaptic activity", EUR J NEURO, 13(7), 2001, pp. 1459-1463

Abstract

Neuronal activity is a requirement for the plasticity and normal development of the central nervous system. We have used differential cloning techniques to identify an immediate-early gene (IEG) that is rapidly induced in neurons by activity in both adult and developmental models of plasticity. Here we describe the key regulatory enzyme of polyamine catabolism, spermidine/ spermine N'-acetyltransferase (SSAT), as a neuronal IEG. In the rat brain, kainate-induced seizures result in a 5.5-fold increase in the amount of SSAT mRNA above basal levels and the enzymatic activity is increased twofold. Expression of SSAT mRNA is rapidly and transiently upregulated in the cerebral cortex and hippocampus by seizure-induced neuronal activation. In hippocampal neurons, SSAT expression is dynamically responsive to synaptic activity in the long-term potentiation (LTP) paradigm. In developing brain, region-specific expression of SSAT mRNA is first detected at postnatal day 9 (P9) and subsequently increases through days P15, P20, before reaching maximal level in adult animals. This dynamic transcriptional and translational control suggests that SSAT may play a role in activity-dependent neuronal plasticity and development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:31:16