Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala
Autore:
Hall, J; Thomas, KL; Everitt, BJ;
Indirizzi:
Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England Univ Cambridge Cambridge England CB2 3EB hol, Cambridge CB2 3EB, England
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 13, anno: 2001,
pagine: 1453 - 1458
SICI:
0953-816X(200104)13:7<1453:FMRICP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR CREB; CAMP-RESPONSIVE ELEMENT; LONG-TERM-MEMORY; C-FOS; CONDITIONED FEAR; CONTEXTUAL FEAR; PROTEIN-SYNTHESIS; MESSENGER-RNA; INDUCTION; RAT;
Keywords:
gene expression; hippocampus; learning and memory; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Thomas, KL Univ Cambridge, Dept Expt Psychol, Downing St, Cambridge CB2 3EB, England Univ Cambridge Downing St Cambridge England CB2 3EB B, England
Citazione:
J. Hall et al., "Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala", EUR J NEURO, 13(7), 2001, pp. 1453-1458

Abstract

Fear memory retrieval has been shown to induce a protein-synthesis dependent re-consolidation of memories within the amygdala, Here, using immunocytochemistry, we investigated the molecular basis of this process in the rat and show that retrieval of a cued fear memory induces the activation, by phosphorylation, of the transcription factor CREB within the basal and lateralnuclei of the amygdala, as well as expression of the CREB-regulated immediate-early gene, c-fos, in the basal amygdala. We also show an increase in CREB phosphorylation within the central nucleus of the amygdala following behavioural testing, with an accompanying increase in Fos-immunoreactive nuclei in animals retrieving the cued association. There were no changes in either phosphorylated CREB or Fos in the hippocampus following exposure to discrete fear stimuli. These results show that activation of CREB, which has been shown to be involved in the formation of long-term fear memories, also accompanies memory retrieval, and also suggest a role for CREB phosphorylation in memory re-consolidation following retrieval.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:16:04