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Titolo:
PSA-NCAM modulates BDNF-dependent survival and differentiation of corticalneurons
Autore:
Vutskits, L; Djebbara-Hannas, Z; Zhang, H; Paccaud, JP; Durbec, P; Rougon, G; Muller, D; Kiss, JZ;
Indirizzi:
Univ Geneva, Sch Med, Dept Morphol, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 Morphol, CH-1211 Geneva 4, Switzerland CNRS 9943, Lab Genet & Physiol Dev, F-13288 Marseille, France CNRS 9943 Marseille France F-13288 hysiol Dev, F-13288 Marseille, France Univ Geneva, Sch Med, Dept Pharmacol, CH-1211 Geneva 4, Switzerland Univ Geneva Geneva Switzerland 4 harmacol, CH-1211 Geneva 4, Switzerland
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 7, volume: 13, anno: 2001,
pagine: 1391 - 1402
SICI:
0953-816X(200104)13:7<1391:PMBSAD>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-ADHESION MOLECULE; LONG-TERM POTENTIATION; POLYSIALIC ACID; N-CAM; NEUROTROPHIC FACTORS; NEURITE OUTGROWTH; AXONAL GROWTH; EXPRESSION; MIGRATION; RECEPTOR;
Keywords:
BDNF; neuronal survival; PSA-NCAM; rat; TrkB;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kiss, JZ Univ Geneva, Sch Med, Dept Morphol, 1 Rue Michel Servet, CH-1211 Geneva 4,Switzerland Univ Geneva 1 Rue Michel Servet Geneva Switzerland 4 Switzerland
Citazione:
L. Vutskits et al., "PSA-NCAM modulates BDNF-dependent survival and differentiation of corticalneurons", EUR J NEURO, 13(7), 2001, pp. 1391-1402

Abstract

We show that the loss or inactivation of the polysialic acid (PSA) tail ofneural cell adhesion molecule (NCAM) on rat cortical neurons in culture leads to reduced differentiation and survival. The mechanism by which this negative effect is mediated appears to involve the neuronal response to brain-derived neurotrophic factor (BDNF): (i) in the absence of PSA or in the presence of excess free PSA added to the culture medium, BDNF-induced cell signalling is reduced; (ii) the addition of exogenous BDNF to the medium reverses the effect of PSA loss or inactivation. These data suggest that PSA-NCAM, previously shown to modulate cell migration and plasticity, is needed for an adequate sensitivity of neurons to BDNF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:43:39