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Titolo:
Age-related changes in brain-behaviour relationships: Evidence from event-related functional MRI studies
Autore:
Rypma, B; DEsposito, M;
Indirizzi:
Univ Calif Berkeley, Dept Psychol, Berkeley, CA 94720 USA Univ Calif Berkeley Berkeley CA USA 94720 Psychol, Berkeley, CA 94720 USA
Titolo Testata:
EUROPEAN JOURNAL OF COGNITIVE PSYCHOLOGY
fascicolo: 1-2, volume: 13, anno: 2001,
pagine: 235 - 256
SICI:
0954-1446(200103/06)13:1-2<235:ACIBRE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; VERBAL WORKING-MEMORY; RECOGNITION MEMORY; NEURAL ACTIVITY; FMRI; ACTIVATION; RETRIEVAL; REGIONS; MODEL; ROLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Rypma, B Univ Calif Berkeley, Dept Psychol, 3210 Tolman Hall, Berkeley, CA94720 USA Univ Calif Berkeley 3210 Tolman Hall Berkeley CA USA 94720 20 USA
Citazione:
B. Rypma e M. D'Esposito, "Age-related changes in brain-behaviour relationships: Evidence from event-related functional MRI studies", EUR J COG P, 13(1-2), 2001, pp. 235-256

Abstract

A fundamental aim of studies in neurocognitive ageing is to understand age-related changes in brain-behaviour relationships. Neuroimaging techniques such as positron emission tomography (PET) and functional magnetic resonance imaging (flMRI) can be used for observation of these age-related changes only if the assumption of age-equivalent relations between neural activity and haemodynamic activity is valid. In one study, we characterised age-related differences in the coupling of the haemodynamic response to neural activity and found greater voxel-wise noise in older than in younger adults, but age-equivalent signal magnitude. These results suggested that alternativetechniques may be necessary for analysing age-related differences in neuroimaging data. In a second study, we utilised one alternative method for comparing fMRI activation between younger and older adults performing a working memory (WM) task. Across three experiments, the results suggested that age-related functional changes in fMRI activation can be isolated to dorsolateral prefrontal cortex (PFC) during memory retrieval. These results suggesta plausible model for WM decline with normal ageing. In a third study we propose and test a model of age-related PFC dysfunction that may account forthese and other age-related differences in cognitive performance.

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Documento generato il 25/01/20 alle ore 15:47:51