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Titolo:
Activation of the Sarcophaga lectin gene promoter by (A+T)-stretch bindingprotein
Autore:
Aozasa, N; Shiraishi, H; Nakanishi-Matsui, M; Kobayashi, A; Sekimizu, K; Kubo, T; Natori, S;
Indirizzi:
Inst Phys & Chem Res, Natori Special Lab, Wako, Saitama 3510198, Japan Inst Phys & Chem Res Wako Saitama Japan 3510198 o, Saitama 3510198, Japan Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 ceut Sci, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 8, volume: 268, anno: 2001,
pagine: 2506 - 2511
SICI:
0014-2956(200104)268:8<2506:AOTSLG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEREGRINA FLESH-FLY; MOLECULAR-CLONING; ANTIBACTERIAL PROTEINS; DROSOPHILA CELLS; INNATE IMMUNITY; SARCOTOXIN-II; PURIFICATION; DNA; LARVAE; TRANSCRIPTION;
Keywords:
ATBP; (A plus T)-stretch; Sarcophaga lectin gene; transcription factor; promoter;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Natori, S Inst Phys & Chem Res, Natori Special Lab, Hirosawa 2-1, Wako, Saitama 3510198, Japan Inst Phys & Chem Res Hirosawa 2-1 Wako Saitama Japan 3510198 pan
Citazione:
N. Aozasa et al., "Activation of the Sarcophaga lectin gene promoter by (A+T)-stretch bindingprotein", EUR J BIOCH, 268(8), 2001, pp. 2506-2511

Abstract

Previously, we purified and isolated a cDNA for (A + T)-stretch binding protein (ATBP) that binds to (A + T)-stretches in the 5' upstream region of the Sarcophaga lectin gene [Nakanishi-Matsui, M., Kubo, T. & Natori, S. (1995) fur: J. Biochem. 230, 396-400]. Here, we used a luciferase reporter to examine the effect of ATBP on transcription of the Sarcophaga lectin gene. Deletion experiments revealed that ATBP activates the Sarcophaga lectin genein a 5' upstream sequence-dependent manner, and that at least the N-terminal 25 residues, the three Zn-finger domains, an acidic domain and the thirdhydrophobic domain of ATBP are indispensable for its function. Furthermore, a synergistic effect was detected between ATBP and Dif, suggesting that ATBP is involved in the activation of insect immunity genes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 22:07:24