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Titolo:
New ideas for medical treatment of congenital adrenal hyperplasia
Autore:
Merke, DP; Cutler, GB;
Indirizzi:
NICHHD, Warren Grant Magnuson Clin Ctr, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 gnuson Clin Ctr, NIH, Bethesda, MD 20892 USA NICHHD, Pediat & Reprod Endocrinol Branch, NIH, Bethesda, MD 20892 USA NICHHD Bethesda MD USA 20892 docrinol Branch, NIH, Bethesda, MD 20892 USA Eli Lilly & Co, Growth & Recovery Res Invest, Indianapolis, IN 46285 USA Eli Lilly & Co Indianapolis IN USA 46285 vest, Indianapolis, IN 46285 USA
Titolo Testata:
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
fascicolo: 1, volume: 30, anno: 2001,
pagine: 121 -
SICI:
0889-8529(200103)30:1<121:NIFMTO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; CENTRAL PRECOCIOUS PUBERTY; CORTISOL PRODUCTION-RATE; 21-HYDROXYLASE DEFICIENCY; ADULT HEIGHT; GROWTH-HORMONE; FINAL HEIGHT; RECEPTOR ANTAGONIST; CUSHINGS-SYNDROME; CONTROLLED TRIAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Merke, DP NICHHD, Warren Grant Magnuson Clin Ctr, NIH, Bldg 10,Room 13S260,10 Ctr DrMSC 1932, Bethesda, MD 20892 USA NICHHD Bldg 10,Room 13S260,10 Ctr Dr MSC 1932 Bethesda MD USA 20892
Citazione:
D.P. Merke e G.B. Cutler, "New ideas for medical treatment of congenital adrenal hyperplasia", END METAB C, 30(1), 2001, pp. 121

Abstract

Since the introduction of glucocorticoid and mineralocorticoid replacementtherapy approximately 50 years ago, the standard treatment principles of 21-hydroxylase deficiency have remained largely unchanged. Glucocorticoid isgiven in doses sufficient to suppress adrenal androgen secretion, and mineralocorticoid is given to normalize electrolytes and plasma renin activity. This treatment strategy often fails to normalize the growth and development of children with congenital adrenal hyperplasia (CAH), and management is often complicated by iatrogenic Gushing's syndrome, inadequately treated hyperandrogenism, and, later in life, infertility. This article addresses theclinical problems patients with CAH continue to have and outlines new ideas for the medical treatment of this condition.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:13:52