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Titolo:
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
Autore:
Ebisawa, T; Uchiyama, M; Kajimura, N; Mishima, K; Kamei, Y; Katoh, M; Watanabe, T; Sekimoto, M; Shibui, K; Kim, K; Kudo, Y; Ozeki, Y; Sugishita, M; Toyoshima, R; Inoue, Y; Yamada, N; Nagase, T; Ozaki, N; Ohara, O; Ishida, N; Okawa, M; Takahashi, K; Yamauchi, T;
Indirizzi:
Saitama Med Sch, Dept Psychiat, Moroyama, Saitama 3500495, Japan Saitama Med Sch Moroyama Saitama Japan 3500495 ma, Saitama 3500495, Japan Natl Ctr Neurol & Psychiat, Dept Psychophysiol, Chiba 2720827, Japan Natl Ctr Neurol & Psychiat Chiba Japan 2720827 iol, Chiba 2720827, Japan NCNP, Musashi Hosp, Tokyo 1870031, Japan NCNP Tokyo Japan 1870031NCNP, Musashi Hosp, Tokyo 1870031, Japan Akita Univ, Sch Med, Dept Psychiat, Akita 0108543, Japan Akita Univ Akita Japan 0108543 Med, Dept Psychiat, Akita 0108543, Japan NCNP, Kohnodai Hosp, Chiba 2720827, Japan NCNP Chiba Japan 2720827NCNP, Kohnodai Hosp, Chiba 2720827, Japan Tokyo Womens Med Coll, Dept Psychiat, Tokyo 1628666, Japan Tokyo Womens Med Coll Tokyo Japan 1628666 Psychiat, Tokyo 1628666, Japan Shiga Univ Med Sci, Dept Psychiat, Shiga 5202192, Japan Shiga Univ Med Sci Shiga Japan 5202192 pt Psychiat, Shiga 5202192, Japan Juntendo Univ, Sch Med, Dept Psychiat, Tokyo 1138431, Japan Juntendo UnivTokyo Japan 1138431 d, Dept Psychiat, Tokyo 1138431, Japan Kazusa DNA Res Inst, Chiba 2920812, Japan Kazusa DNA Res Inst Chiba Japan 2920812 A Res Inst, Chiba 2920812, Japan Fujita Hlth Univ, Sch Med, Dept Psychiat, Aichi 4701192, Japan Fujita HlthUniv Aichi Japan 4701192 Dept Psychiat, Aichi 4701192, Japan
Titolo Testata:
EMBO REPORTS
fascicolo: 4, volume: 2, anno: 2001,
pagine: 342 - 346
SICI:
1469-221X(200104)2:4<342:AOSPIT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
KINASE-I-EPSILON; CIRCADIAN CLOCK; NUCLEAR ENTRY; DISORDERS; MAMMALS; MPER3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Ebisawa, T Saitama Med Sch, Dept Psychiat, 38 Morohongo, Moroyama, Saitama3500495, Japan Saitama Med Sch 38 Morohongo Moroyama Saitama Japan 3500495pan
Citazione:
T. Ebisawa et al., "Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome", EMBO REP, 2(4), 2001, pp. 342-346

Abstract

Recent progress in biological clock research has facilitated genetic analysis of circadian rhythm sleep disorders, such as delayed sleep phase syndrome (DSPS) and non-24-h sleep-wake syndrome (N-24). We analyzed the human period3 (hPer3) gene, one of the human homologs of the Drosophila clock-gene period (Per), as a possible candidate for rhythm disorder susceptibility. All of the coding exons in the hPer3 gene were screened for polymorphisms bya PCR-based strategy using genomic DNA samples from sleep disorder patients and control subjects. We identified six sequence variations with amino acid changes, of which five were common and predicted four haplotypes of the hPer3 gene. One of the haplotypes was significantly associated with DSPS (Bonferroni's corrected P = 0.037; odds ratio = 7.79; 95% CI 1.59-38.3) in our study population. Our results suggest that structural polymorphisms in the hPer3 gene may be implicated in the pathogenesis of DSPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:13:43