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Titolo:
Homologous recombination in planta is stimulated in the absence of Rad50
Autore:
Gherbi, H; Gallego, ME; Jalut, N; Lucht, JM; Hohn, B; White, CI;
Indirizzi:
Univ Blaise Pascal, UMR BIOMOVE 6547, F-63177 Clermont Ferrand, France Univ Blaise Pascal Clermont Ferrand France F-63177 rmont Ferrand, France Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
EMBO REPORTS
fascicolo: 4, volume: 2, anno: 2001,
pagine: 287 - 291
SICI:
1469-221X(200104)2:4<287:HRIPIS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOUBLE-STRAND BREAKS; END-JOINING REPAIR; SACCHAROMYCES-CEREVISIAE; ILLEGITIMATE RECOMBINATION; DNA-REPAIR; 2 PATHWAYS; YEAST; MUTATIONS; GENES; MRE11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: White, CI Univ Blaise Pascal, UMR BIOMOVE 6547, 24 Ave Landais, F-63177 Clermont Ferrand, France Univ Blaise Pascal 24 Ave Landais Clermont Ferrand France F-63177
Citazione:
H. Gherbi et al., "Homologous recombination in planta is stimulated in the absence of Rad50", EMBO REP, 2(4), 2001, pp. 287-291

Abstract

Chromosomal double-strand DNA breaks must be repaired; in the absence of repair the resulting acentromeric (and telomere-less) fragments may be lost and/or the broken DNA ends may recombine causing general chromosomal instability. The Rad50/Mre11/Xrs2 protein complex acts at DNA ends and is implicated in both homologous and non-homologous recombination. We have isolated arad50 mutant of the plant Arabidopsis thaliana and show here that it has asomatic hyper-recombination phenotype in planta. This finding supports thehypothesis of a competition between homologous and illegitimate recombination in higher eukaryotes. To our knowledge, this is the first direct in vivo support for the role of this complex in chromosomal recombination in a multicellular organism and the first description of a mutation of a known gene leading to hyper-recombination in plants.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 02:35:00