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Titolo:
METABOLIC EVALUATION OF PATIENTS WITH RECURRENT IDIOPATHIC CALCIUM NEPHROLITHIASIS
Autore:
HESS B; HASLERSTRUB U; ACKERMANN D; JAEGER P;
Indirizzi:
UNIV HOSP BERN,DEPT MED CH-3010 BERN SWITZERLAND UNIV HOSP BERN,POLICLIN MED CH-3010 BERN SWITZERLAND UNIV HOSP BERN,DEPT UROL CH-3010 BERN SWITZERLAND
Titolo Testata:
Nephrology, dialysis, transplantation
fascicolo: 7, volume: 12, anno: 1997,
pagine: 1362 - 1368
SICI:
0931-0509(1997)12:7<1362:MEOPWR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL STONE FORMERS; URINARY CITRATE; KIDNEY-STONE; AMBULATORY EVALUATION; EXCRETION; PROTEIN; CALCULI;
Keywords:
HYPERCALCIURIA; HYPEROXALURIA; HYPOCITRATURIA; IDIOPATHIC CALCIUM NEPHROLITHIASIS; LOW URINE VOLUME; METABOLIC EVALUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B. Hess et al., "METABOLIC EVALUATION OF PATIENTS WITH RECURRENT IDIOPATHIC CALCIUM NEPHROLITHIASIS", Nephrology, dialysis, transplantation, 12(7), 1997, pp. 1362-1368

Abstract

Background. Metabolic evaluation in recurrent idiopathic calcium renal stone-formers (RCSF) was analysed with respect to the following questions: (1) do three 24-h urines provide more diagnostic accuracy in the metabolic evaluation of RCSF than 1 or 2 urines?; (2) does time after stone event influence the diagnostic yield?; (3) is urine composition at weekends different from that at mid-week?; (4) what are the prevalences of the most important risk factors (RF) of idiopathic calcium nephrolithiasis, i.e. low volume (LV), hypercalciuria (HC), hyperoxaluria (HO), hyperuricosuria (HU), hypocitraturia (Hypo-Cit), and hypomagnesiuria (Hypo-Mg)?; and (5) do male RCSF differ from females with respect to urinary RFs? Methods. Seventy-five RCSF (59 men, 16 women) collected three 24-h urines (U1-3) while on free-choice diet. To account for possible variations in lifestyle and diet, U1 and U3 had to be collected midweek and U2 at a weekend. Results. When considering all threeurines together (U1 + U2 + U3), the number of RF abnormalities/patient was 2.8 +/- 0.1, higher than numbers of any combination of two urines or of any single urine (P = 0.0001 for all comparisons). The number of RF abnormalities also rose with time after stone event, from 0.8 +/- 0.1 (range 0-4) in U1 to 1.1 +/- 0.1 (range 0-4) in U3 (P = 0.011 vsU1). Whereas all other RF did not change between collections, urine volume was lower in U2 (1793 +/- 90 ml) than in U1 (2071 +/- 97 ml, P =0.0001 vs U2) and U3 (1946 +/- 97 ml, P = 0.046 vs U2). At least 1 abnormality was found in 85.3% of all RCSF, and multiple abnormalities occurred in 47%. The most frequent RF was HC (39%), followed by HO and LV (32% each), Hypo-Cit (29%), HU (23%) and Hypo-mg (19%). Males more often had Hypo-Cit (P< 0.001) and Hypo-Mg (P<0.01) than females, whereas HO was more frequent in female RCSF (P<0.025 vs males). Conclusions. Diagnostic accuracy of metabolic evaluation in RCSF increases both with the number of urines collected and the time passing after a stone event. Urines collected at weekends differ from those of the week onlyby their lower volumes. Abnormalities of RF for calcium nephrolithiasis can be detected in 85.3% of RCSF, and HC is the most-common RF bothin male and female RCSF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 08:23:10