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Titolo:
Early-generated preplate neurons in the developing telencephalon: Inward migration into the developing striatum
Autore:
Hamasaki, T; Goto, S; Nishikawa, S; Ushio, Y;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Neurosurg, Neurobiol Lab, Kumamoto 8608556, Japan Kumamoto Univ Kumamoto Japan 8608556 robiol Lab, Kumamoto 8608556, Japan
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 5, volume: 11, anno: 2001,
pagine: 474 - 484
SICI:
1047-3211(200105)11:5<474:EPNITD>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING CEREBRAL-CORTEX; CAJAL-RETZIUS CELLS; MESSENGER-RNA EXPRESSION; LATERAL OLFACTORY TRACT; MARGINAL ZONE; CALRETININ IMMUNOREACTIVITY; HORSERADISH-PEROXIDASE; SOMATOSENSORY CORTEX; MONOCLONAL-ANTIBODY; GANGLIONIC EMINENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Goto, S Kumamoto Univ, Sch Med, Dept Neurosurg, Neurobiol Lab, Honjo 1-1-1, Kumamoto 8608556, Japan Kumamoto Univ Honjo 1-1-1 Kumamoto Japan 8608556o 8608556, Japan
Citazione:
T. Hamasaki et al., "Early-generated preplate neurons in the developing telencephalon: Inward migration into the developing striatum", CEREB CORT, 11(5), 2001, pp. 474-484

Abstract

Specialized subsets of early-generated neurons provide the cellular cues that are necessary for the establishment of characteristic cell and fiber interactions in each brain region. During the development of the mammalian cerebral cortex, the early-generated cells line up in the most superficial part of the telencephalic pallium forming the preplate. It has been generallythought that the preplate derivatives are exclusively located in the cortical region and govern the early histogenetic phase of cortical development. However, we here disclose an unexpected evidence that a subset of early-generated neurons of the piriform preplate migrate inward into and disperse within the subcortical structure striatum during the embryonic stage. Their migratory route is unique and its direction is opposite to the ordinary migration of neuronal precursors directed outward from the periventricular germinal zone. After immigrating into the developing striatum, these early-generated cells are closely associated with the intrastriatal fascicules of axons. The majority of these cells are eliminated by apoptotic cell death during the early postnatal stage. Based on these findings, we propose a new concept: the preplate neurons may not only direct cortical histogenesis but also change their location to play a role in the development of subcortical structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 04:31:57