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Titolo:
D-1 dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons
Autore:
Wang, J; ODonnell, P;
Indirizzi:
Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA Albany Med Coll Albany NY USA 12208 acol & Neurosci, Albany, NY 12208 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 5, volume: 11, anno: 2001,
pagine: 452 - 462
SICI:
1047-3211(200105)11:5<452:DDRPNE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT NUCLEUS-ACCUMBENS; SPATIAL WORKING-MEMORY; DEPENDENT PROTEIN-KINASE; IN-VITRO; NEOSTRIATAL NEURONS; ELECTROPHYSIOLOGICAL RESPONSES; REGULATED PHOSPHOPROTEIN; SYNAPTIC TRANSMISSION; NEOCORTICAL NEURONS; UNRESTRAINED RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: O'Donnell, P Albany Med Coll, Ctr Neuropharmacol & Neurosci, MC-136, Albany, NY 12208 USA Albany Med Coll MC-136 Albany NY USA 12208 bany, NY 12208 USA
Citazione:
J. Wang e P. O'Donnell, "D-1 dopamine receptors potentiate NMDA-mediated excitability increase in layer V prefrontal cortical pyramidal neurons", CEREB CORT, 11(5), 2001, pp. 452-462

Abstract

The interactions between N-methyl-D-aspartate (NMDA) and D-1 dopamine receptors in the rat prefrontal cortex were examined using whole-cell recordings from pyramidal neurons. The effects of NMDA, the D-1 agonist SKF38393, orboth compounds combined were tested on measures of cell excitability. BothNMDA (10-100 muM) and SKF38393 (5-10 muM) independently increased the number at spikes and decreased the latency of the first spike evoked by intracellular depolarizing current pulses. Combining low doses of NMDA (5 muM) andSKF38393 (2 muM) resulted in a marked increase of cell excitability. This synergism was blocked by SCH23390, protein kinase A (PKA) inhibitors, and the Ca2+ chelator BAPTA, and reduced by nifedipine, These results indicate the presence of a dopamine-glutamate interaction in the prefrontal cortex atthe postsynaptic level, by which D1 dopamine receptors may maintain NMDA-mediated responses in prefrontal cortical pyramidal neurons through both a PKA-dependent pathway and Ca2+-dependent mechanisms.

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Documento generato il 02/04/20 alle ore 11:48:12