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Titolo:
Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex
Autore:
Stanwood, GD; Washington, RA; Levitt, P;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA
Titolo Testata:
CEREBRAL CORTEX
fascicolo: 5, volume: 11, anno: 2001,
pagine: 430 - 440
SICI:
1047-3211(200105)11:5<430:IOASPO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL CORTICAL-NEURONS; IN-UTERO; PREFRONTAL CORTEX; BRAIN-DEVELOPMENT; RHESUS-MONKEY; ADULT-RABBITS; VISUAL-CORTEX; D-1 RECEPTOR; RAT-BRAIN; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Stanwood, GD Univ Pittsburgh, Sch Med, Dept Neurobiol, E1440 Biomed Sci Tower, Pittsburgh, PA 15261 USA Univ Pittsburgh E1440 Biomed Sci Tower Pittsburgh PA USA 15261
Citazione:
G.D. Stanwood et al., "Identification of a sensitive period of prenatal cocaine exposure that alters the development of the anterior cingulate cortex", CEREB CORT, 11(5), 2001, pp. 430-440

Abstract

Administration of cocaine to pregnant rabbits produces robust and long lasting anatomical, neurochemical and behavioral alterations in their offspring. For example, exposure to cocaine following implantation [embryonic day (E) 8] through gestation (E29) produces increased length and decreased bundling of layer HI and V pyramidal neuron dendrites, increased parvalbumin expression in the dendrites of interneurons, and increased GABA levels in the anterior cingulate cortex (ACC) and other dopamine-rich cortical areas. We have investigated the presence of a sensitive period of in utero exposure during specific developmental epochs prior to and during the onset of cortical development that might be capable of producing such effects. Cocaine (3 mg/kg i.v., twice daily) or saline was administered during embryonic days E16-E25 (onset and peak of corticogenesis), E8-E15 (prior to cortical plate formation), E8-E25 or E8-E29 as in earlier studies. Examination of the ACC in offspring exposed from E8 to E25 and from E16 to E25 were found to induce alterations in the development of pyramidal neurons and interneurons thatare nearly identical to those induced by the complete exposure (E8-E29) paradigm. No alterations were observed following the E8-E15 cocaine exposure. These data suggest that exposure to cocaine during E16-E25, the time of peak corticogenesis, appearance of cortical monoamines and onset of Dr dopamine receptor expression, is necessary and sufficient to produce long-term effects on the organization of excitatory pyramidal neurons and inhibitory interneurons in the ACC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 14:30:19