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Titolo:
Relatives of prostate cancer patients have an increased risk of prostate and stomach cancers: a population-based, cancer registry study in Finland
Autore:
Matikainen, MP; Pukkala, E; Schleutker, J; Tammela, TLJ; Koivisto, P; Sankila, R; Kallioniemi, OP;
Indirizzi:
Univ Tampere, Inst Med Technol, Canc Genet Lab, FIN-33101 Tampere, FinlandUniv Tampere Tampere Finland FIN-33101 t Lab, FIN-33101 Tampere, Finland Tampere Univ Hosp, Dept Surg, Div Urol, FIN-33101 Tampere, Finland TampereUniv Hosp Tampere Finland FIN-33101 , FIN-33101 Tampere, Finland Seinajoki Cent Hosp, Dept Surg, Seinajoki, Finland Seinajoki Cent Hosp Seinajoki Finland sp, Dept Surg, Seinajoki, Finland Finnish Canc Registry, FIN-00170 Helsinki, Finland Finnish Canc Registry Helsinki Finland FIN-00170 00170 Helsinki, Finland Int Agcy Res Canc, Unit Descript Epidemiol, F-69372 Lyon, France Int Agcy Res Canc Lyon France F-69372 pt Epidemiol, F-69372 Lyon, France NHGRI, Canc Genet Branch, NIH, Bethesda, MD 20892 USA NHGRI Bethesda MD USA 20892 anc Genet Branch, NIH, Bethesda, MD 20892 USA
Titolo Testata:
CANCER CAUSES & CONTROL
fascicolo: 3, volume: 12, anno: 2001,
pagine: 223 - 230
SICI:
0957-5243(2001)12:3<223:ROPCPH>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILIAL GASTRIC-CANCER; ANDROGEN RECEPTOR GENE; BREAST-CANCER; E-CADHERIN; SUSCEPTIBILITY LOCUS; DOMINANT INHERITANCE; CHROMOSOME 13Q12-13; HISTORY; MEN; MUTATIONS;
Keywords:
cancer risk; prostatic neoplasms; registry-based study; relatives;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Matikainen, MP Univ Tampere, Inst Med Technol, Canc Genet Lab, POB 607, FIN-33101 Tampere, Finland Univ Tampere POB 607 Tampere Finland FIN-33101 re, Finland
Citazione:
M.P. Matikainen et al., "Relatives of prostate cancer patients have an increased risk of prostate and stomach cancers: a population-based, cancer registry study in Finland", CANC CAUSE, 12(3), 2001, pp. 223-230

Abstract

Objective: Five to ten percent of prostate cancers may be caused by inherited genetic defects. In order to explore the nature of inherited cancer risks in the genetically homogeneous Finnish population, we investigated the incidence of prostate cancer and other cancers in first-degree relatives of prostate cancer patients by linking the population-based parish records on relatives with the Finnish Cancer Registry (FCR) data. Methods: The study population was composed of first-degree relatives of two groups of prostate cancer patients diagnosed in Finland during 1988-1993:(1) all early-onset (less than or equal to 60years) patients (n=557) from the entire country, (2) a sample (n=989) of prostate cancer patients diagnosed at an age of > 60 years. A total of 11,427 first-degree relatives were identified through parish records, and their cancer incidence was determined based on a total of 299,970 person-years. Standardized incidence ratios (SIR) were calculated based on expected cancer rates in the general population. Results: The SIR of prostate cancer was increased in both Cohort 1 (2.5, 95% CI 1.9-3.2) and Cohort 2 (1.7, 95% CI 1.4-2.1). The risk of prostate cancer was high for relatives of patients diagnosed at an early age, and then leveled off for patients in the median age of prostate cancer diagnosis (70-79 years). However, the prostate cancer risk for relatives of patients diagnosed greater than or equal to 80years was again statistically significantly elevated (SIR 1.8, 95% CI 1.3-2.6), suggesting a contribution of geneticfactors to prostate cancer also at a late age of onset. Gastric cancer wasthe only other cancer type with a significantly elevated risk among the relatives. Increased risk of gastric cancer was seen only in male relatives of prostate cancer patients diagnosed at an early age, with the highest riskdetected for the male relatives of prostate cancer patients diagnosed at an age of 55 years or less (SIR 5.0, 95% CI 2.8-8.2). Conclusions: Our population-based study indicates that hereditary factors may play an important role in the development of prostate cancer among the relatives of men diagnosed both at younger and older ages. This finding is relevant in the context of our observations that HPCX (hereditary prostate cancer susceptibility locus on Xq27-28) linkage in Finland is found exclusively among families with late age of onset. The association of gastric cancer with prostate cancer has not been reported previously, and may reflect the effects of a novel predisposition locus, which increases the risk to both of these common tumor types.

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Documento generato il 24/10/20 alle ore 14:55:52