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Titolo:
Lumbar vertebral cancellous bone is capable of responding to PGE(2) treatment by stimulating both modeling and remodeling-dependent bone gain in agedmale rats
Autore:
Zhou, H; Ma, YF; Yao, W; Cui, L; Setterberg, R; Liang, CT; Jee, WSS;
Indirizzi:
Univ Utah, Sch Med, Div Radiobiol, Salt Lake City, UT 84108 USA Univ UtahSalt Lake City UT USA 84108 obiol, Salt Lake City, UT 84108 USA Natl Hlth Res Inst, Taipei 115, Taiwan Natl Hlth Res Inst Taipei Taiwan 115 l Hlth Res Inst, Taipei 115, Taiwan Helen Hayes Hosp, Reg Bone Ctr, W Haverstraw, NY 10993 USA Helen Hayes Hosp W Haverstraw NY USA 10993 tr, W Haverstraw, NY 10993 USA Lilly Corp Ctr, Indianapolis, IN 46285 USA Lilly Corp Ctr Indianapolis INUSA 46285 Ctr, Indianapolis, IN 46285 USA
Titolo Testata:
CALCIFIED TISSUE INTERNATIONAL
fascicolo: 3, volume: 68, anno: 2001,
pagine: 179 - 184
SICI:
0171-967X(200103)68:3<179:LVCBIC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIECTOMIZED RATS; POSTMENOPAUSAL WOMEN; PARATHYROID-HORMONE; MINERAL DENSITY; RENAL-CELLS; WISTAR RATS; DONOR AGE; MARROW; PROLIFERATION; RESORPTION;
Keywords:
prostaglandin E-2; lumbar vertebra; histomorphometry; modeling; remodeling;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Jee, WSS Univ Utah, Sch Med, Div Radiobiol, Salt Lake City, UT 84108 USA Univ Utah Salt Lake City UT USA 84108 lt Lake City, UT 84108 USA
Citazione:
H. Zhou et al., "Lumbar vertebral cancellous bone is capable of responding to PGE(2) treatment by stimulating both modeling and remodeling-dependent bone gain in agedmale rats", CALCIF TIS, 68(3), 2001, pp. 179-184

Abstract

Previously we found that PGE(2) 3 mg/kg in 20-month-old male rats induced massive bone formation mainly by modeling dependent bone gain in cortical bone. It is not known whether cancellous bone will respond similarly; thus, we evaluated the effect of PGE(2) on cancellous bone of the same aged rats. Thirty-four 20-month-old Wistar male rats were given PGE(2) (3 mg/kg/day) or vehicle subcutanously for 10 and 30 days. Double fluorescent labels wereinjected 9 and 2 days prior to the sacrifice. Histomorphometry was performed on 1% toluidine blue stained and unstained sagittal sections of lumbar vertebral bodies. The results demonstrated that 10-day PGE(2) treatment increased osteoprogenitor cells, osteoblasts (x2-fold), osteoid (x4.5-fold), woven bone formation (0.04%), and 40% more trabecular area; it stimulated modeling (x2-fold) and remodeling-dependent (x1.5-fold) bone formation with increase of mineralization lag time (MLT, x 7.5-fold). Thirty-day treatment sustained increases in osteoblast numbers, modeling, and remodeling-dependent bone formation and further stimulated woven bone formation (6.6%), turnover (x3-fold), and trabecular area and number (x2-fold). Osteoprogenitor cells were undetectable along with 70% less osteoid area compared with 10-day treatment but still was 1.5-fold higher than aging controls. MLT returned to aging control level. It was concluded that the aged cancellous bone of 20-month-old male Wistar rat retains a capability of responding to the anabolic effect of PGE(2). Osteoblastogenesis and enhanced modeling and remodeling-dependent woven or lamellar formation contribute to this anabolic action. Bone formation differed in that the endocortical surface of cortical bone was stimulated mainly by modeling whereas both modeling and remodeling-dependent bone gain were equally stimulated at the trabecular surface of the lumbar vertebral body.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 15:53:01