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Titolo:
Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies
Autore:
Ohnuma, K; Isoyama, K; Ikuta, K; Toyoda, Y; Nakamura, J; Nakajima, F; Tsuchida, M; Ohira, M; Suminoe, A; Hara, T;
Indirizzi:
Univ Tokyo, Div Clin Immunol, Inst Med Sci,Adv Clin Res Ctr, Minato Ku, Tokyo 1088639, Japan Univ Tokyo Tokyo Japan 1088639 Res Ctr, Minato Ku, Tokyo 1088639, Japan Showa Univ, Fujigaoka Hosp, Dept Paediat, Yokohama, Kanagawa 227, Japan Showa Univ Yokohama Kanagawa Japan 227 iat, Yokohama, Kanagawa 227, Japan Yokohama City Univ Hosp, Dept Transfus Med, Yokohama, Kanagawa, Japan Yokohama City Univ Hosp Yokohama Kanagawa Japan okohama, Kanagawa, Japan Kanagawa Childrens Med Ctr, Dept Oncol, Yokohama, Kanagawa, Japan KanagawaChildrens Med Ctr Yokohama Kanagawa Japan hama, Kanagawa, Japan Kanagawa Prefecture Red Cross Blood Ctr, Div Lab 3, Yokohama, Kanagawa, Japan Kanagawa Prefecture Red Cross Blood Ctr Yokohama Kanagawa Japan a, Japan Ibaraki Childrens Hosp, Mitoshi, Japan Ibaraki Childrens Hosp Mitoshi Japan aki Childrens Hosp, Mitoshi, Japan Natl Canc Ctr, Div Paediat, Tokyo 104, Japan Natl Canc Ctr Tokyo Japan 104 tl Canc Ctr, Div Paediat, Tokyo 104, Japan Kyushu Univ, Grad Sch Med Sci, Dept Paediat, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812 Med Sci, Dept Paediat, Fukuoka 812, Japan
Titolo Testata:
BRITISH JOURNAL OF HAEMATOLOGY
fascicolo: 4, volume: 112, anno: 2001,
pagine: 981 - 987
SICI:
0007-1048(200103)112:4<981:CBTFHU>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEMATOPOIETIC STEM-CELLS; VERSUS-HOST DISEASE; PLACENTAL-BLOOD; CHRONIC GRAFT; RECIPIENTS; OUTCOMES; BANK;
Keywords:
cord blood transplantation; HLA mismatching; haematological malignancy; unrelated donors; children;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Ohnuma, K Univ Tokyo, Div Clin Immunol, Inst Med Sci,Adv Clin Res Ctr, Minato Ku, 4-6-1 Shirokanedai, Tokyo 1088639, Japan Univ Tokyo 4-6-1 Shirokanedai Tokyo Japan 1088639 088639, Japan
Citazione:
K. Ohnuma et al., "Cord blood transplantation from HLA-mismatched unrelated donors as a treatment for children with haematological malignancies", BR J HAEM, 112(4), 2001, pp. 981-987

Abstract

Factors influencing the outcome for 39 children with haematological malignancy who were subjected to a cord blood transplantation (CBT) from genotypically HLA-mismatched unrelated donors were analysed. This retrospective study included 21 children with acute lymphoblastic leukaemia, 15 with acute myelogenous leukaemia and one each with chronic myelogenous leukaemia, refractory anaemia with myelodysplastic syndrome (MDS) and juvenile myelomonocytic leukaemia (JMML), Those subjected to CBT during the first or second complete remission (CR) and MDS without blasts were assigned to the standard-risk (SR) group (n = 16), Patients in third or subsequent remission, relapse or partial remission with refractory leukaemia at the time of CBT were considered to be in advanced phase, and placed in the high-risk (IIR) group (n = 11), JMML and the second CR after a relapse (n = 8), or bone marrow failure after a rejection (n = 3), following haematopoietic stem cell transplantation (HSCT) in the first CR were included in the high-risk group, Kaplan-Meier estimates for neutrophil and platelet recovery were 83.7 +/- 12.2 at d60 and 55.4 +/- 16.6% at d 100 respectively. The incidence of grades ii-Vtacute graft-versus-host disease was 58.5 +/- 16.8%. The Kaplan-Meier estimate for 3-year event-free survival (EFS) was 49.2 +/- 16.6. From multivariate analysis, the most important factor influencing EFS was disease status at CBT: SR patients had 3-year EFS of 75.0 +/- 21.6%, compared with 29.6 +/-20.6% for those with HR disease (P = 0.013, RR 4.746, 95% CI 1.382-16.298). These data confirm that HLA-mismatched, unrelated CBT is a feasible procedure to cure a significant proportion of children with leukaemia, especially if conducted in a favourable phase of the disease.

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Documento generato il 19/01/20 alle ore 09:26:11