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Titolo:
Angioimmunoblastic lymphadenopathy-type peripheral T-cell lymphoma with cutaneous infiltration: report of a case and its gene expression profile
Autore:
Murakami, T; Ohtsuki, M; Nakagawa, H;
Indirizzi:
Jichi Med Sch, Dept Dermatol, Minami Kawachi, Tochigi 3290498, Japan JichiMed Sch Minami Kawachi Tochigi Japan 3290498 Tochigi 3290498, Japan
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 144, anno: 2001,
pagine: 878 - 884
SICI:
0007-0963(200104)144:4<878:ALPTLW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLICE-INHIBITORY PROTEIN; IMMUNOBLASTIC LYMPHADENOPATHY; LYMPHOPROLIFERATIVE DISORDERS; CHEMOATTRACTANT FACTOR; MYCOSIS-FUNGOIDES; GAMMA-INTERFERON; IN-VITRO; RECEPTOR; DYSPROTEINEMIA; PATTERNS;
Keywords:
angioimmunoblastic T-cell lymphoma; cDNA microarray; cutaneous involvement; gene expression;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Murakami, T Jichi Med Sch, Dept Dermatol, 3311-1 Yakushiji, Minami Kawachi, Tochigi 3290498, Japan Jichi Med Sch 3311-1 Yakushiji Minami Kawachi Tochigi Japan 3290498
Citazione:
T. Murakami et al., "Angioimmunoblastic lymphadenopathy-type peripheral T-cell lymphoma with cutaneous infiltration: report of a case and its gene expression profile", BR J DERM, 144(4), 2001, pp. 878-884

Abstract

Angioimmunoblastic T-cell lymphoma is a type of peripheral. T-cell lymphoma that is clinically characterized by high fever and generalized lymphadenopathy with or without cutaneous involvement. A 55-year-old Japanese man presented with red papular lesions on the trunk and limbs, oedema, and generalized lymphadenopathy, Histological findings in the lymph nodes showed destructive germinal centres, proliferation of arborizing postcapillary venules,and atypical medium-sized lymphocytes, The cutaneous lesions also contained atypical lymphocytes. Immunohistochemical studies indicated that the neoplastic cells were mature CD4+ T lymphocytes. Southern blot analysis detected a clonal expansion of T-cell receptor beta. Based on these findings, a diagnosis of angioimmunoblastic T-cell lymphoma with cutaneous infiltration was made. Despite systemic chemotherapy, the disease exhibited a high level of activity and continued on a fatal course, An analysis of gene expressionprofiling using complementary DNA microarrays revealed significant expression of some chemokines and cytokines, e.g. secondary lymphoid tissue chemokine, macrophage inflammatory protein (MIP)-1 beta, MIP-3 alpha, MIP-3 beta,B-lymphocyte chemokine, interleukin-16 and tumour necrosis factor-beta, and an apoptosis-inhibitory protein (FLICE inhibitory protein) in the affected lymph nodes. Profiling of gene expression patterns for a variety of genesin additional cases may be helpful in determining which factors predict the biological and clinical behaviour of angioimmunoblastic T-cell lymphoma or other aggressive malignant lymphomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:32:44