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Titolo:
Cytokine gene polymorphisms in psoriasis
Autore:
Craven, NM; Jackson, CW; Kirby, B; Perrey, C; Pravica, V; Hutchinson, IV; Griffiths, CEM;
Indirizzi:
Univ Manchester, Hope Hosp, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD lford M6 8HD, Lancs, England Univ Manchester, Dept Immunol, Manchester, Lancs, England Univ ManchesterManchester Lancs England nol, Manchester, Lancs, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 144, anno: 2001,
pagine: 849 - 853
SICI:
0007-0963(200104)144:4<849:CGPIP>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; SUCTION BLISTER FLUIDS; BONE-MARROW TRANSPLANTATION; COLONY-STIMULATING FACTOR; FACTOR-ALPHA GENE; TNF-ALPHA; TRANSFORMING GROWTH-FACTOR-BETA-1; PROMOTER POLYMORPHISM; DISEASE SEVERITY; GAMMA-INTERFERON;
Keywords:
interferon-gamma; interleuliin-10; interleukin-4; psoriasis; Th1; Th2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, CEM Univ Manchester, Hope Hosp, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD ancs, England
Citazione:
N.M. Craven et al., "Cytokine gene polymorphisms in psoriasis", BR J DERM, 144(4), 2001, pp. 849-853

Abstract

Background Cytokine production is under genetic control, and certain allelic variants of cytokine genes are associated with higher or lower cytokine production in vitro and in vivo. Psoriasis is associated with an overexpression in the involved skin of T-helper cell type 1 (Th1) cytokines, e.g. interferon (IFN) -gamma and tumour necrosis factor (TNF) alpha and relative underexpression of Th2 cytokines, e.g. interleukin (IL) -4 and IL-10. Objective We investigated the hypothesis that allelic variants of genes for a high production of Th1 cytokines or TNF-alpha, or conversely low production of Th2 cytokines might represent a risk factor for developing psoriasis. Methods Genotyping for IFN-gamma, IL-10, IL-4 and TNF-alpha was undertakenfor 84 patients with psoriasis and compared with control data on file. Results Genotype frequencies showed no differences between patients and controls for IFN-gamma, TNF-alpha or IL-4. For IL-10, patients with late onset psoriasis (over 40 years) were more likely to be heterozygous at position- 1082 (P = 0.02), corresponding to intermediate production of IL-10 in vitro and in vivo. Conclusions Psoriasis is not determined by a genotype consistent with highproduction of Th1 cytokines or low production of Th2 cytokines. Thus, the Th1 cytokine profile found in psoriatic plaques is most likely a consequence of local factors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 04:27:22