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Titolo:
Increased frequency of HLA-DR6 allele in Italian patients with hepatitis Cvirus-associated oral lichen planus
Autore:
Carrozzo, M; Di Celle, PF; Gandolfo, S; Carbone, M; Conrotto, D; Fasano, ME; Roggero, S; Rendine, S; Ghisetti, V;
Indirizzi:
Univ Turin, Sch Med & Dent, Dept Oral Med, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 Dent, Dept Oral Med, I-10126 Turin, Italy Univ Turin, Sch Med & Dent, Dept Genet, I-10126 Turin, Italy Univ Turin Turin Italy I-10126 & Dent, Dept Genet, I-10126 Turin, Italy Univ Turin, Sch Med & Dent, Dept Biol & Biochem, I-10126 Turin, Italy UnivTurin Turin Italy I-10126 Dept Biol & Biochem, I-10126 Turin, Italy Molinette Hosp, UAOD, Turin, Italy Molinette Hosp Turin ItalyMolinette Hosp, UAOD, Turin, Italy Molinette Hosp, UAO, Clin Microbiol Lab, Turin, Italy Molinette Hosp Turin Italy Hosp, UAO, Clin Microbiol Lab, Turin, Italy
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 144, anno: 2001,
pagine: 803 - 808
SICI:
0007-0963(200104)144:4<803:IFOHAI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II ALLELES; HLA CLASS-II; BRITISH PATIENTS; HCV INFECTION; ANTIGENS; GENOTYPES; DISEASE; SUSCEPTIBILITY; HETEROGENEITY; PREVALENCE;
Keywords:
hepatitis C virus; HLA antigens; lichen planus; oral lichen planus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Carrozzo, M Univ Turin, Sch Med & Dent, Dept Oral Med, Cso Dogliotti 14, I-10126 Turin, Italy Univ Turin Cso Dogliotti 14 Turin Italy I-10126 Turin, Italy
Citazione:
M. Carrozzo et al., "Increased frequency of HLA-DR6 allele in Italian patients with hepatitis Cvirus-associated oral lichen planus", BR J DERM, 144(4), 2001, pp. 803-808

Abstract

Background Recent controlled studies have confirmed that hepatitis C virus(HCV) is the main correlate of liver disease in patients with lichen planus (LP), mainly in southern Europe and Japan, However, a low prevalence of HCV infection has been found in LP patients in England and northern France, and significant differences in serum HCV RNA levels or HCV genotypes have not been found between LP patients and controls. Thus host rather than viralfactors may be prevalent in the pathogenesis of HCV-related LP. The HLA-DRallele may influence both the outcome of HCV infection and the appearance of symptoms outside the liver. Objectives To assess whether major histocompatibility complex class II alleles play a part in the development of HCV-related LP. Methods Intermediate-resolution DRB typing by hybridization with oligonucleotide probes was performed in 44 consecutive Italian oral LP (OLP) patients with HCV infection (anti-HCV and HCV RNA positive), in an age, sex and clinically comparable disease control group of 60 Italian OLP patients without HCV infection (anti-HCV and HCV RNA negative), and in 145 healthy unrelated Italian bone marrow donors without evidence of liver disease or history of LP and with negative tests for HCV,Results Patients with exclusive OLP and HCV infection possessed the HLA-DRG allele more frequently than patients with exclusive OLP but without HCV infection (52% vs. 18%, respectively; P-c (P-corrected) = 0.028, relative risk = 4.93). We did not find any relationship between mucocutaneous LP, HCV infection and HLA-DR alleles,Conclusions HCV-related OLP therefore appears to be a distinctive subset particularly associated with the HLA class II allele HLA-DRG, This could partially explain the peculiar geographical heterogeneity of the association between HCV and LP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:26:13