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Titolo:
The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels
Autore:
Harman, KE; Seed, PT; Gratian, MJ; Bhogal, BS; Challacombe, SJ; Black, MM;
Indirizzi:
St Thomas Hosp, St Johns Inst Dermatol, London SE1 7EH, England St Thomas Hosp London England SE1 7EH Dermatol, London SE1 7EH, England Guys Hosp, Dept Publ Hlth Sci, London SE1 9RT, England Guys Hosp London England SE1 9RT Publ Hlth Sci, London SE1 9RT, England Univ London Kings Coll, Guys Kings & St Thomas Sch Med & Dent, Guys Hosp, Dept Oral Med & Pathol, London, England Univ London Kings Coll London England ral Med & Pathol, London, England
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 144, anno: 2001,
pagine: 775 - 780
SICI:
0007-0963(200104)144:4<775:TSOCAO>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIRECT IMMUNOFLUORESCENCE; VULGARIS ANTIGEN; DISEASE-ACTIVITY; PATHOGENIC AUTOANTIBODIES; FOLIACEUS AUTOANTIBODIES; EXTRACELLULAR DOMAIN; IGG SUBCLASSES; CELL-ADHESION; SERA; PHENOTYPE;
Keywords:
cutaneous involvement; desmoglein 1; desmoglein 3; oral involvement; pemphigus foliaceus; pemphigus vulgaris;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Harman, KE St Thomas Hosp, St Johns Inst Dermatol, Lambeth Palace Rd, London SE1 7EH,England St Thomas Hosp Lambeth Palace Rd London England SE1 7EHngland
Citazione:
K.E. Harman et al., "The severity of cutaneous and oral pemphigus is related to desmoglein 1 and 3 antibody levels", BR J DERM, 144(4), 2001, pp. 775-780

Abstract

Background Pemphigus vulgaris (PV) and foliaceus (PF) are characterized byantibodies to the desmosomal proteins desmoglein 3 (Dsg3) and desmoglein 1(Dsg1), respectively. Past studies using indirect immunofluorescence (IIF)as a measure of pemphigus antibody levels have failed to demonstrate consistently a relationship between disease severity and IIF titres. However, IIF is not able to measure separately Dsg1 and 3 antibodies, unlike enzyme-linked immunosorbent assays (ELISA), which utilize recombinant proteins. Objectives To compare independently Dsg1 and 3 antibody levels with the severity of both cutaneous and oral involvement in PV and PEPatients and methods Four hundred and twenty-four serum samples were analysed from 80 subjects with PV and 24 with PE IgG antibodies to Dsg1 and 3 were measured by ELISA, For every sample analysed, the associated severity ofskin and oral disease were graded from 0 to 3; quiescent, mild, moderate and severe. Results A relationship between Dsg1 antibodies and skin severity was demonstrated such that a 10-unit increase in Dsg1 ELISA value was associated with a 34% chance of having a higher severity score [95% confidence interval (CI), 25-45%, P < 0.0005]. This was observed in both PV and PE Oral severitywas associated with Dsg3 antibody levels and a 10-unit increase in the Dsg3 ELISA value was associated with a 25% chance of a higher oral severity score (CT 17-33%, P < 0.0005). We were unable to demonstrate a relationship between Dsg1 antibodies and oral severity, even after adjusting for the effect of Dsg3 antibodies, Similarly, there was no relationship between Dsg3 antibodies and skin severity,Conclusions This study suggests that the clinical phenotype of pemphigus, in particular the balance of skin and oral disease, is determined principally by the quantities of Dsg1 and 3 autoantibodies, respectively.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:15:02