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Titolo:
Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans
Autore:
Griffiths, CEM; Cumberbatch, M; Tucker, SC; Dearman, RJ; Andrew, S; Headon, DR; Kimber, I;
Indirizzi:
Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD lford M6 8HD, Lancs, England Hope Hosp, Dept Pathol, Salford M6 8HD, Lancs, England Hope Hosp Salford Lancs England M6 8HD ol, Salford M6 8HD, Lancs, England Syngenta Cent Toxicol Lab, Macclesfield, Cheshire, England Syngenta Cent Toxicol Lab Macclesfield Cheshire England heshire, England Agennix Inc, Houston, TX USA Agennix Inc Houston TX USAAgennix Inc, Houston, TX USA
Titolo Testata:
BRITISH JOURNAL OF DERMATOLOGY
fascicolo: 4, volume: 144, anno: 2001,
pagine: 715 - 725
SICI:
0007-0963(200104)144:4<715:ETLIAL>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NECROSIS-FACTOR-ALPHA; DRAINING LYMPH-NODES; DENDRITIC CELLS; INTERLEUKIN-1-BETA; SIGNALS;
Keywords:
cutaneous inflammation; epidermal cytokines; lactoferrin; Langerhans cells; skin sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Griffiths, CEM Univ Manchester, Dermatol Ctr, Salford M6 8HD, Lancs, England Univ Manchester Salford Lancs England M6 8HD ancs, England
Citazione:
C.E.M. Griffiths et al., "Exogenous topical lactoferrin inhibits allergen-induced Langerhans cell migration and cutaneous inflammation in humans", BR J DERM, 144(4), 2001, pp. 715-725

Abstract

Background Lactoferrin (LF), an iron-binding protein found in exocrine secretions, is known to possess antibacterial properties. It has recently beenproposed that LF may also influence inflammatory reactions. Objectives To characterize in humans the ability of recombinant homologousLF to inhibit the induced migration of epidermal Langerhans cells (LCs) from the skin, a process known to be dependent upon the proinflammatory cytokines tumour necrosis factor (TNF)-alpha and interleukin 1 beta and to influence cutaneous inflammatory reactions. Methods We investigated the anti-inflammatory properties of LF in human volunteers. Results Topical exposure to LF 2 h prior to sensitization caused a significant reduction in contact allergen (diphenylcyclopropenone, DPC)-induced LCmigration from the epidermis as judged by the altered frequency of cells expressing either HLA-DR or CD1a determinants. That this reduction was secondary to an inhibition of TNF-alpha production was indicated by the fact that LF failed to influence LC migration induced by intradermal injection of this cytokine. In approximately 50% of those volunteers who displayed local inflammation in response to DPC, LF was found to cause a discernible reduction in the clinical severity of the reaction, associated with reduced infiltration of inflammatory cells. Conclusions These data demonstrate that LF is able to influence cutaneous immune and inflammatory responses, possibly because of an impaired production of local proinflammatory cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:39:40