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Titolo:
A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat
Autore:
Kohsaka, A; Watanobe, H; Kakizaki, Y; Suda, T; Schioth, HB;
Indirizzi:
Hirosaki Univ, Dept Internal Med 3, Sch Med, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Uppsala Univ, Dept Neurosci, BMC, SE-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden SE-75124 osci, BMC, SE-75124 Uppsala, Sweden Melacure Therapeut, Uppsala, Sweden Melacure Therapeut Uppsala SwedenMelacure Therapeut, Uppsala, Sweden
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 898, anno: 2001,
pagine: 166 - 170
SICI:
0006-8993(20010413)898:1<166:ASPOOA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPOTHALAMIC NEUROPEPTIDES; MEDIAN-EMINENCE; FEMALE RATS; LEPTIN; BRAIN; OREXIN/HYPOCRETIN; HYPOCRETINS; PITUITARY; SECRETION; NEURONS;
Keywords:
orexin; luteinizing hormone surge; prolactin surge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Watanobe, H Hirosaki Univ, Dept Internal Med 3, Sch Med, 5 Zaifu Cho, Hirosaki, Aomori0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 Japan
Citazione:
A. Kohsaka et al., "A significant participation of orexin-A, a potent orexigenic peptide, in the preovulatory luteinizing hormone and prolactin surges in the rat", BRAIN RES, 898(1), 2001, pp. 166-170

Abstract

Orexins are novel hypothalamic peptides which stimulate food intake. In view of the well-known tight connection between the nutritional state and thereproductive function, in this study we examined a possible role of orexin-A in the generation of ovarian steroid-induced luteinizing hormone (LH) and prolactin (PRL) surges in ovariectomized rats. Experiments were performedon both normally-fed and 3-day-fasted rats. Although fasting led to abolition of both LH and PRL surges, intracerebroventricular administration of orexin-A (0.3 and 3.0 nmol) resulted in a dose-dependent recovery of the hormonal surges. In addition, anti-orexin-A antisera given to normally-fed ratscompletely abrogated the surges of both hormones. These results demonstrate for the first time a significant participation of orexin-A in the preovulatory LH and PRL surges in the rat. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:02:10