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Titolo:
Regulation of sensorimotor gating in rats by hippocampal NMDA: anatomical localization
Autore:
Swerdlow, NR; Hanlon, FM; Henning, L; Kim, YK; Gaudet, I; Halim, ND;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Psychiat, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 ychiat, La Jolla, CA 92093 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 898, anno: 2001,
pagine: 195 - 203
SICI:
0006-8993(20010420)898:2<195:ROSGIR>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC STARTLE RESPONSE; DOPAMINE-GLUTAMATE INTERACTIONS; PREPULSE INHIBITION DEFICITS; MEDIAL PREFRONTAL CORTEX; SCHIZOPHRENIC-PATIENTS; NUCLEUS-ACCUMBENS; VENTRAL HIPPOCAMPUS; ENTORHINAL CORTEX; MONOZYGOTIC TWINS; DENTATE GYRUS;
Keywords:
entorhinal cortex; hippocampus; prepulse inhibition; schizophrenia; sensorimotor gating; startle;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Swerdlow, NR Univ Calif San Diego, Sch Med, Dept Psychiat, 9500 Gillman Dr, La Jolla, CA 92093 USA Univ Calif San Diego 9500 Gillman Dr La Jolla CA USA 92093 SA
Citazione:
N.R. Swerdlow et al., "Regulation of sensorimotor gating in rats by hippocampal NMDA: anatomical localization", BRAIN RES, 898(2), 2001, pp. 195-203

Abstract

Prepulse inhibition (PPI) of the startle reflex is a measure of sensorimotor gating that is reduced in humans with certain neuropsychiatric disorders, including schizophrenia, and in rats after manipulations of limbic cortico-striato-pallido-pontine circuitry. We have reported that PPI is reduced after specific manipulations of the hippocampal complex (HPC) in rats, but the mechanisms for these effects remain poorly understood. For example, dopaminergic substrates clearly regulate PPI, but the PPI-disruptive effects ofintra-HPC carbachol or NR IDA are not reversed by D2 receptor antagonists. This study examined the anatomical specificity within the hippocampal complex: of the PPI-disruptive effects of NMDA infusion. Startle magnitude and PPT were assessed after acute bilateral infusion of NR;IDA (0, 0.4 or 0.8 mug) into the dorsal subiculum (DS), region CA1, the ventral subiculum (VS),the rostral entorhinal cortex (ECr) and the caudal entorhinal cortex (ECc). A dorsal-ventral gradient for NMDA effects was observed, with a dose-dependent disruption of PPI after NMDA infusion into the VS or EC, but not the DS, and with intermediate level effects observed after NMDA infusion into CA1. A second set of studies confirmed that the failure of NMDA effects in the DS did not reflect site-related differences in startle magnitude or baseline levels of PPI. These findings demonstrate the importance of the ventral, but not the dorsal HFC, in the glutamatergic regulation of PPI. (C) 2001Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:47:26