Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Magnetization transfer of fluoxetine in the human brain using fluorine magnetic resonance spectroscopy
Autore:
Strauss, WL; Dager, SR;
Indirizzi:
Univ Washington, Sch Med, Dept Psychiat & Behav Sci, Seattle, WA 98105 USAUniv Washington Seattle WA USA 98105 t & Behav Sci, Seattle, WA 98105 USA Univ Washington, Sch Med, Dept Radiol, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 , Dept Radiol, Seattle, WA 98105 USA Univ Washington, Sch Med, Dept Bioengn, Seattle, WA 98105 USA Univ Washington Seattle WA USA 98105 Dept Bioengn, Seattle, WA 98105 USA
Titolo Testata:
BIOLOGICAL PSYCHIATRY
fascicolo: 9, volume: 49, anno: 2001,
pagine: 798 - 802
SICI:
0006-3223(20010501)49:9<798:MTOFIT>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; FLUVOXAMINE; PHARMACOKINETICS;
Keywords:
F-19; MRS; MRI; fluoxetine; magnetization transfer; neuropharmacology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Dager, SR Univ Washington, Sch Med, Dept Psychiat & Behav Sci, 4225 Roosevelt Way NE,Suite 306-C, Seattle, WA 98105 USA Univ Washington 4225 Roosevelt Way NE,Suite 306-C Seattle WA USA 98105
Citazione:
W.L. Strauss e S.R. Dager, "Magnetization transfer of fluoxetine in the human brain using fluorine magnetic resonance spectroscopy", BIOL PSYCHI, 49(9), 2001, pp. 798-802

Abstract

Fluorine magnetic resonance spectroscopy (F-19 MRS) measurements of fluoxetine and metabolite concentration in the human brain underestimate true drug levels because of a bound, MRS-"invisible" pool of drug molecules, Magnetization transfer (MT) spectroscopy may be a useful technique for characterizing this bound pool of fluoxetine in the brain. Six subjects on consistentdaily doses of fluoxetine underwent F-19 MT spectroscopy on a 1.5-T scanner using a train of three preparation pulses at -3000 Hz off resonance with 0.5 W of peak power deposition in tissue. One subject was scanned at multiple time points after initiation of drug therapy. Magnetization transfer signal contrast was quantified using VARPRO-based time domain fitting software. Magnetization transfer signal contrast was quantifiable with mean MT signal depression of 12.5% (SD = 5.0, n = 6). An inverse relationship between brain concentration and the MT signal contrast of fluoxetine was found (r = -.82, Spearman coefficient = .007). This study is the first in vivo application of F-19 MT spectroscopy and the first to demonstrate a quantifiable MTeffect for a psychotropic medication in the human brain. Findings suggest that fluoxetine is substantially bound in the brain and that individual differences, inversely related to brain concentration, can be detected in the magnitude of MT contrast. (C) 2001 Society of Biological Psychiatry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 09:26:14