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Titolo:
TEOAE monitoring of Cisplatin induced ototoxicity in guinea pigs: the protective effect of vitamin B treatment
Autore:
Guneri, EA; Serbetcioglu, B; Ikiz, AO; Guneri, A; Ceryan, K;
Indirizzi:
Dokuz Eylul Univ, Sch Med, Dept Otorhinolaryngol, TR-3540 Izmir, Turkey Dokuz Eylul Univ Izmir Turkey TR-3540 inolaryngol, TR-3540 Izmir, Turkey
Titolo Testata:
AURIS NASUS LARYNX
fascicolo: 1, volume: 28, anno: 2001,
pagine: 9 - 14
SICI:
0385-8146(200101)28:1<9:TMOCIO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUDITORY HAIR-CELLS; OTOACOUSTIC EMISSIONS; TESTICULAR-CANCER; DOSE CISPLATIN; INDUCED DAMAGE; HEARING-LOSS; ACID; COCHLEA;
Keywords:
guinea pigs; otoacoustic emissions; ototoxicity; vitamin B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Guneri, EA Mithatpasa Cad 146-12, TR-35260 Izmir, Turkey Mithatpasa Cad 146-12 Izmir Turkey TR-35260 260 Izmir, Turkey
Citazione:
E.A. Guneri et al., "TEOAE monitoring of Cisplatin induced ototoxicity in guinea pigs: the protective effect of vitamin B treatment", AURIS NAS L, 28(1), 2001, pp. 9-14

Abstract

Objective: To evaluate Cisplatin (CP) induced ototoxicity and the effects of vitamin B treatment on ototoxicity in guinea pigs by using the TransientEvoked Otoacoustic Emission (TEOAE) technique. Methods: Eleven guinea pigswere divided into two groups and they were tested by TEOAE before and after the experiment. A TEOAE response was regarded as positive when all of thefollowing criteria were met: 1. The mean amplitude of the cochlear response in dB pe SPL should be greater than that of the noise in the external auditory canal; 2. The reproducibility rate of the response should be greater than 50%; 3. The stimulus stability rate should be greater than 65%; 4. Thesignal to noise ratio of the response in 1, 2, 3, 4 and 5 kHz band frequencies should be greater than 3 dB pe SPL in at least two bands. The first group included five animals that had only CP injections. Six animals in the second group received additional 0.2 ml/kg combined vitamin B preparations for 7 consecutive days. Thereafter, the right and left ears of all animals in both groups were tested by TEOAE. Results: TEOAE responses recorded from 22 ears of 11 guinea pigs before drug administrations showed that the responses with maximum amplitude were originated from the mid-frequency legion. Positive TEOAE responses were significantly reduced after CP administrations in both groups when compared with their respective pretreatment results (P < 0.01). However, vitamin B injections, in addition to a single large dose of CP, resulted in significantly better TEOAE responses than those obtained after only CP injections (P < 0.05). Conclusions: The routine use of TEOAE monitoring is recommended in clinical CP treatment protocols for the early detection and follow up of ototoxicity. Also, prospective clinical trials are needed in order to validate the protective effects of vitamin B treatment against ototoxicity. (C) 2001 Elsevier Science Ireland Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:51:05