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Titolo:
IRF family of transcription factors as regulators of host defense
Autore:
Taniguchi, T; Ogasawara, K; Takaoka, A; Tanaka, N;
Indirizzi:
Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Immunol, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo, Fac Med, Bunkyo Ku, Tokyo 1130033, Japan Univ Tokyo Tokyo Japan 1130033 Fac Med, Bunkyo Ku, Tokyo 1130033, Japan
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 19, anno: 2001,
pagine: 623 - 655
SICI:
0732-0582(2001)19:<623:IFOTFA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEQUENCE-BINDING-PROTEIN; INTERFERON CONSENSUS SEQUENCE; IFN-BETA-GENE; NATURAL-KILLER-CELLS; ALPHA-STIMULATED TRANSCRIPTION; INDUCIBLE ENHANCER ELEMENT; HELPER TYPE-1 CELLS; FUNCTION IN-VIVO; T-CELLS; TARGETED DISRUPTION;
Keywords:
interferon; cytokine; interferon regulatory factor; transcriptional regulation; oncogenes;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
189
Recensione:
Indirizzi per estratti:
Indirizzo: Taniguchi, T Univ Tokyo, Grad Sch Med, Dept Immunol, Bunkyo Ku, Hongo 7-3-1, Tokyo 1130033, Japan Univ Tokyo Hongo 7-3-1 Tokyo Japan 1130033 yo 1130033, Japan
Citazione:
T. Taniguchi et al., "IRF family of transcription factors as regulators of host defense", ANN R IMMUN, 19, 2001, pp. 623-655

Abstract

Interferon regulatory factors (IRFs) constitute a family of transcription factors that commonly possess a novel helix-turn-helix DNA-binding motif. Following the initial identification of two structurally related members, IRF-1 and IRF-2, seven additional members have now been reported. In addition, virally encoded IRFs, which may interfere with cellular IRFs, have also been identified. Thus far, intensive functional analyses have been done on IRF-1, revealing a remarkable functional diversity of this transcription factor in the regulation of cellular response in host defense. Indeed, IRF-1 selectively modulates different sets of genes, depending on the cell type and/or the nature of cellular stimuli, in order to evoke appropriate responses in each. More recently, much attention has also been focused on other IRFfamily members. Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:59:21