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Titolo:
In vivo activation of antigen-specific CD4 T cells
Autore:
Jenkins, MK; Khoruts, A; Ingulli, E; Mueller, DL; McSorley, SJ; Reinhardt, RL; Itano, A; Pape, KA;
Indirizzi:
Univ Minnesota, Sch Med, Dept Microbiol, Ctr Immunol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 mmunol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Med, Ctr Immunol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 mmunol, Minneapolis, MN 55455 USA Univ Minnesota, Sch Med, Dept Pediat, Ctr Immunol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 mmunol, Minneapolis, MN 55455 USA
Titolo Testata:
ANNUAL REVIEW OF IMMUNOLOGY
, volume: 19, anno: 2001,
pagine: 23 - 45
SICI:
0732-0582(2001)19:<23:IVAOAC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASS-II COMPLEXES; IN-VIVO; DENDRITIC CELLS; CLONAL EXPANSION; PERIPHERAL TOLERANCE; RECEPTOR OCCUPANCY; EFFECTOR FUNCTION; GERMINAL-CENTERS; LEISHMANIA-MAJOR; LYMPHOID ORGANS;
Keywords:
CD4 T cells; in vivo immune response; immunological memory; dendritic cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
102
Recensione:
Indirizzi per estratti:
Indirizzo: Jenkins, MK Univ Minnesota, Sch Med, Dept Microbiol, Ctr Immunol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 eapolis, MN 55455 USA
Citazione:
M.K. Jenkins et al., "In vivo activation of antigen-specific CD4 T cells", ANN R IMMUN, 19, 2001, pp. 23-45

Abstract

Physical detection of antigen-specific CD4 T cells has revealed features of the in vivo immune response that were not appreciated from in vitro studies. In vivo, antigen is initially presented to naive CD4 T cells exclusively by dendritic cells within the T cell areas of secondary lymphoid tissues. Anatomic constraints make it likely that these dendritic cells acquire theantigen at the site where it enters the body. Inflammation enhances in vivo T cell activation by stimulating dendritic cells to migrate to the T cellareas and display stable peptide-MHC complexes and costimulatory ligands. Once stimulated by a dendritic cell, antigen-specific CD4 T cells produce IL-2 but proliferate in an IL-2-independent fashion. Inflammatory signals induce chemokine receptors on activated T cells that direct their migration into the B cell areas to interact with antigen-specific B cells. Most of theactivated T cells then die within the lymphoid tissues. However, in the presence of inflammation, a population of memory T cells survives. This population is composed of two functional classes. One recirculates through nonlymphoid tissues and is capable of immediate effector lymphokine production. The other recirculates through lymph nodes and quickly acquires the capacity to produce effector lymphokines if stimulated. Therefore, antigenic stimulation in the presence of inflammation produces an increased number of specific T cells capable of producing effector lymphokines throughout the body.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 16:09:48