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Titolo:
FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: Comparison with spiral CT
Autore:
Franzius, C; Daldrup-Link, HE; Sciuk, J; Rummeny, EJ; Bielack, S; Jurgens, H; Schober, O;
Indirizzi:
Univ Hosp, Dept Nucl Med, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Nucl Med, Munster, Germany Univ Hosp, Dept Clin Radiol, Munster, Germany Univ Hosp Munster GermanyUniv Hosp, Dept Clin Radiol, Munster, Germany Univ Hosp, Dept Pediat Hematol & Oncol, Munster, Germany Univ Hosp Munster Germany Dept Pediat Hematol & Oncol, Munster, Germany
Titolo Testata:
ANNALS OF ONCOLOGY
fascicolo: 4, volume: 12, anno: 2001,
pagine: 479 - 486
SICI:
0923-7534(200104)12:4<479:FFDOPM>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; F-18 FLUORODEOXYGLUCOSE; OSTEOGENIC-SARCOMA; OSTEOSARCOMA; CHEMOTHERAPY; SCINTIGRAPHY; NODULES; IMAGES; ONCOLOGY;
Keywords:
Ewing's sarcoma; FDG-PET; malignant primary bone tumors; osteosarcoma; pulmonary metastases; thoracic CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Franzius, C Univ Munster, Dept Nucl Med, Albert Schweitzer Str 33, D-48149Munster, Germany Univ Munster Albert Schweitzer Str 33 Munster Germany D-48149
Citazione:
C. Franzius et al., "FDG-PET for detection of pulmonary metastases from malignant primary bone tumors: Comparison with spiral CT", ANN ONCOL, 12(4), 2001, pp. 479-486

Abstract

Background: The purpose was the comparison of positron emission tomographyusing F-18-fluorodeoxy-glucose (FDG-PET) and spiral thoracic CT to detect pulmonary metastases from malignant primary osseous tumors. Patients and methods: In 71 patients with histologically confirmed malignant primary bone tumors (32 osteosarcomas, 39 Ewing's sarcomas) 111 FDG-PET examinations were evaluated with regard to pulmonary/pleural metastases in comparison with spiral thoracic CT. Reference methods were the clinical follow-ups for 6-64 months (median 20 months) or a histopathologic analysis. Results: In 16 patients (23%) reference methods revealed a pulmonary/pleural metastatic disease. FDG-PET had a sensitivity of 0.50, a specificity of 0.98, and an accuracy of 0.87 on a patient based analysis. Comparable values for spiral CT were 0.75, 1.00, and 0.94. It was shown that no patient whohad a true positive FDG-PET had a false negative CT scan, nor was a pulmonary metastases detected earlier by FDG-PET than by spiral CT. Conclusions: There seems to be a superiority of spiral CT in the detectionof pulmonary metastases from malignant primary bone tumors as compared with FDG-PET. Therefore, at present a negative FDG-PET cannot be recommended to exclude lung metastases. However, as specificity of FDG-PET is high, a positive FDG-PET result can be used to confirm abnormalities seen on thoracicCT scans as metastatic.

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Documento generato il 16/01/21 alle ore 03:52:19