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Titolo:
Twenty-four hours of activity of cetirizine and fexofenadine in the skin
Autore:
Purohit, A; Duvernelle, C; Melac, M; Pauli, G; Frossard, N;
Indirizzi:
Hop Univ B, INSERM, Serv Pneumol, Strasbourg, France Hop Univ B Strasbourg France , INSERM, Serv Pneumol, Strasbourg, France Fac Pharm, U425, INSERM, F-67401 Illkirch, France Fac Pharm Illkirch France F-67401 U425, INSERM, F-67401 Illkirch, France UCB Pharma, Nanterre, France UCB Pharma Nanterre FranceUCB Pharma, Nanterre, France
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 4, volume: 86, anno: 2001,
pagine: 387 - 392
SICI:
1081-1206(200104)86:4<387:THOAOC>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEASONAL ALLERGIC RHINITIS; CHRONIC IDIOPATHIC URTICARIA; DOUBLE-BLIND; PLACEBO; EFFICACY; SAFETY; LORATADINE; HYDROCHLORIDE; TERFENADINE; HISTAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Frossard, N Fac Pharm, U425, INSERM, BP 24, F-67401 Illkirch, France Fac Pharm BP 24 Illkirch France F-67401 7401 Illkirch, France
Citazione:
A. Purohit et al., "Twenty-four hours of activity of cetirizine and fexofenadine in the skin", ANN ALLER A, 86(4), 2001, pp. 387-392

Abstract

Background: Cetirizine and fexofenadine, the active metabolite of terfenadine, are powerful and well-tolerated H-1 receptor antagonists effective in the treatment of skin and nose atopic diseases. Objective: We have compared the pharmacodynamic activity of the two antihistamines at therapeutic dosages, cetirizine at 10 mg and fexofenadine at 120 mg and 180 mg, on histamine-induced skin reactivity during a 24-hour period after single intake. Methods: Twenty-six healthy volunteers participated in a randomized, double-blind, crossover, placebo-controlled study. The areas of wheal and flare induced by histamine (100 mg/mL) administered by prick test were measured at 0, 0.5, 1, 2, 4, 6, 8, 10, 12, and 24 hours postdose. Statistical analysis of the areas under the time-response curves was performed by a Friedman'sANOVA followed by a Wilcoxon test and Bonferroni's correction. Results: The three active treatments clearly inhibited the wheal and flareareas throughout the 24-hour period compared with placebo. Maximal inhibition occurred at 4 hours postdose. Between 4 and 24 hours postdose, the timecourse of inhibition by cetirizine differed significantly (P < 0.001) fromthat by fexofenadine at either dose, which did not differ from each other. At 24 hours, fexofenadine inhibited <40% of the skin reaction, whereas cetirizine reduced 60% of the wheal. The duration of effect, considered as thetime for wheal to be inhibited by at least 70%, also significantly favoredcetirizine (19 hours) compared with fexofenadine (9.3 and 8.5 hours for 180 and 120 mg, respectively; P < 0.001). Consistency of activity was evaluated by the frequency of total inhibition of the wheal (<greater than or equal to>95%). Consistency was observed in 26 of 26 participants for cetirizine, 21 of 26 for fexofenadine, 180 mg, and 10 of 26 for fexofenadine, 120 mg (P < 0.001), suggesting better consistency for cetirizine. There was no serious adverse event. Conclusions: Our study clearly shows better duration of action and consistency of the antihistaminic activity of cetirizine compared with fexofenadine (120 and 180 mg) in the histamine-induced skin reaction during a 24-hour period.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/10/20 alle ore 09:01:48